Intern – Biology Technologies
About The Position
Cytokinetics is a specialty cardiovascular biopharmaceutical company, building on its over 25 years of pioneering scientific innovations in muscle biology, and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction. At Cytokinetics, each team member plays an integral part in advancing our mission to improve the lives of patients. We are seeking tenacious, compassionate, and collaborative individuals who are driven to make a positive impact. The Biology Technologies Intern will own a defined summer project focused on developing, optimizing, and validating a reproducible phosphoproteomics workflow for use across Biology Technologies programs. Working closely with the Advanced Mass Spectrometry group, the intern will establish a robust analytical method leveraging the Bruker timsTOF flex platform and Spectronaut for data analysis. This project will result in a documented, validated workflow that supports downstream target engagement and drug discovery efforts. This is an onsite internship. Candidates must be able to work in person at the South San Francisco office.
Requirements
- Have completed at least two to four years at a US college or university at the time of the program with a focus in Biochemistry.
- Prior lab experience in biology or chemistry required with experience in biochemical assays preferred.
- Must be detail oriented and have a proactive attitude in support of research activities and running assays
- Highly focused, organized and motivated team player with good time management skills
- Excellent communication skills and the ability to troubleshoot problems with team members
Nice To Haves
- Pursuing a Graduate degree preferred.
- Prior experience in statistics/ data analysis is preferred.
- Experience with mammalian cell culture preferred
Responsibilities
- Develop and document a reproducible phosphopeptide enrichment protocol for Biology Technologies
- Optimize LC-MS acquisition parameters on the Bruker timsTOF flex for phosphoproteomics applications
- Establish and validate a complete phosphoproteomics workflow from sample preparation through data analysis
- Validate workflow performance using a defined biological perturbation to assess method robustness
- Analyze and interpret phosphoproteomics datasets using Spectronaut
- Apply the validated workflow to selected Biology Technologies targets
- Maintain detailed experimental documentation and contribute to method standardization efforts
- Provide regular project updates in group meetings and deliver a final presentation summarizing results and recommendations
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What This Job Offers
Career Level
Intern
Education Level
No Education Listed
Number of Employees
251-500 employees
