Head of Process Analytical Technology - Mammalian Platform

Sanofi•Framingham, MA

8h•Onsite

About The Position

Join the engine of Sanofi’s mission — where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive breakthroughs that could turn the impossible into possible for millions. Are you ready to help create the future of biomanufacturing? At Sanofi, we strive every day to Take the Lead to innovate for patients with novel therapeutics and manufacturing technology. Your leadership skills and expertise in Process Analytical Technology (PAT) could be a key enabler that helps us realize that future together. The Mammalian Platform (part of Sanofi R&D) is responsible for the development, scale-up, and transfer of upstream and downstream processes and their control strategies for clinical and commercial manufacturing of therapeutic proteins produced from mammalian cell lines. In addition, the department actively invests in developing and implementing new technologies related to integrated and continuous biomanufacturing, process analytical technology (PAT), high throughput process development, and modeling. Ultimately, our goal is to design robust processes that produce safe and effective medicines as efficiently as possible. We are looking for candidates to lead our Process Analytical Technology activities across the Mammalian Platform including applications for both cell culture and purification processes. This individual should be able to combine innovation leadership skills with technical expertise to continuously evolve and lead teams in the delivery of our Process Analytical Technology roadmap. The incumbent will lead in a matrixed structure, leveraging resources across the platform’s global footprint in both the United States (Framingham, MA) and France (Vitry) while representing the platform at the interface with our Commercial Manufacturing and Supply (M&S) organization. This role will report to the Global Head of Purification Development, providing a direct link to Mammalian Platform leadership to support sustained innovation and technology implementation in both clinical and commercial manufacturing applications.

Requirements

PhD. in Biochemical Engineering, Chemical Engineering, Analytical Chemistry, Physics, Bioengineering, Electrical Engineering, or related fields with at least 7 years of experience or a M.S. with at least 11 years of relevant experience or a B.S. with at least 12 years of relevant experience
Relevant industrial experience and/or academic experience in Process Analytical Technology development

Nice To Haves

Experience with spectroscopic Process Analytical Technology (Raman, Near-Infrared, Mid-Infrared, Fluorescence, UV-Vis) techniques
Experience with online or inline analyzers for Process Analytical Technology applications (HPLC, UPLC, LCMS, DLS, MALS) and auto-sampling techniques
Understanding of PAT-enabling digital architecture and its application in manufacturing settings (SynTQ, SIMCA-Online, Distributed Control Systems)
Familiarity with relevant Regulatory and Quality frameworks related to control strategy, method qualification, process validation, and data integrity
Understanding of upstream and downstream unit operations, process development, and technology transfer
Understanding of product quality attributes of therapeutic proteins (antibodies, multi-specific antibodies, fusion proteins, enzymes)
Ability to lead a diverse, cross-functional, cross-site matrixed team
Excellent communication skills in both written and oral settings
High level of scientific curiosity and innovation mindset

Responsibilities

Lead the development and implementation of Process Analytical Technology for the Mammalian Platform, including cell culture and purification applications
Drive the design and evolution of our Process Analytical Technology roadmap to enable near-term implementation and long-term disruptive innovation
Represent the Mammalian Platform for PAT-related topics, interfacing with Commercial Manufacturing and Quality, as well as other Platforms within R&D (Microbial, Genomic Medicines, mRNA, Vaccines, Synthetics)
Engage relevant stakeholders across R&D and Commercial Manufacturing to ensure resources, budget, and implementation risk are adequately managed and communicated
Identify opportunities to improve our process development strategies and manufacturing approaches through the application of PAT
Act as a PAT champion across the Sanofi R&D and Manufacturing network
Mentor scientists across sites and teams fostering their career development and professional growth

Benefits

Bring the miracles of science to life alongside a supportive, future-focused team.
Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

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