Graduate Intern - Antibody Repertoire Bioinformatics

Bio-Techne • Minneapolis, MN

2d • $17 - $23

About The Position

By joining Bio-Techne, you’ll join a company with a powerful and positive purpose of enabling cutting-edge research in Life Sciences and Clinical Diagnostics. Bio-Techne, and all of its brands, provides tools for researchers to further treat and prevent disease worldwide. Pay Range: $16.80 - $23.10 Project Summary: We are seeking a motivated graduate intern to develop and implement a bioinformatics pipeline for identifying paired heavy and light chain antibody sequences from single-cell RNA sequencing data. The intern will build a customized immunoglobulin gene reference data set, run and optimize a V(D)J informatics pipeline, and perform clonotype analysis and preliminary repertoire characterization. This project supports ongoing antibody development in our lab, with opportunities to contribute to novel repertoire discovery. Pay Rate: $24.00 an hour

Requirements

• Current graduate student in bioinformatics, computational biology, molecular biology, or related field.
• Familiarity with Linux command line and scripting (bash, Python, or R).
• Basic knowledge of immunology and antibody biology preferred.
• Experience with next-generation sequencing data processing.
• Strong critical thinking skills and ability to work independently.
• Excellent communication and documentation skills.
• Must be a currently enrolled student pursuing a graduate-level degree in a field relevant to the internship
• Must be able to work full-time during the duration of the internship program

Nice To Haves

• Experience with single-cell RNA-seq or immune repertoire analysis.
• Knowledge of workflows such as 10x Genomics data formats and Cell Ranger software.
• Familiarity with immunoglobulin gene annotation tools (IgBlast, MiXCR, TRUST4).

Responsibilities

• Curate and assemble V(D)J germline gene reference databases suitable for input to V(D)J informatics pipelines.
• Build and validate custom reference files.
• Process raw single-cell RNA-seq FASTQ datasets.
• Troubleshoot pipeline runs and optimizes parameters.
• Analyze output clonotype and chain pairing data; generate summary reports and visualizations.
• Document protocols, workflows, and develop reusable scripts for the project.
• Collaborate with lab members to interpret biological relevance of antibody repertoires.

Benefits

• We offer competitive insurance benefits starting on day one: medical, dental, vision, life, short-term disability, long-term disability, pet, and legal and ID shield.
• We invest in our employees’ financial futures through 401k plans, an employee stock purchase plan (ESPP), Health Saving Account (HSA), Flexible Spending Account (FSA), and Dependent Care FSA.
• We empower our employees develop their careers through mentorship, promotional opportunities, training and development, tuition reimbursement, internship programs, and more.
• We offer employee resource groups, volunteer paid time off, employee events, and charity drives to build a culture of caring and belonging.
• We offer an accrued leave policy with paid holidays, paid time off, and paid parental leave.
• We foster a culture of empowerment and innovation, where employees feel valued and encouraged to bring their new ideas to the table.

What This Job Offers

• Job Type: Full-time
• Career Level: Intern