Global HEOR Director

BioNTech•Berkeley Heights, NJ

About The Position

As the Global HEOR Director, you will be at the forefront of advancing BioNTech’s mission by driving impactful health economics and outcomes research strategies. In this role, you will shape value evidence-based approaches that contribute to global market access and reimbursement success, ensuring patients worldwide benefit from our innovative therapies. You’ll collaborate with cross-functional teams in a dynamic environment that values scientific rigor and methodological advancements. Your work will directly influence clinical development decisions, regulatory submissions, and payer communications & interactions. By leveraging your expertise in HEOR methodologies, real-world evidence, and cost-effectiveness analysis, you’ll play a pivotal role in enhancing BioNTech’s ability to deliver transformative treatments to diverse populations.

Requirements

MS required; Doctoral degree (PhD/PharmD/MD) preferred in Public Health, Epidemiology, Health Economics, or related fields with significant experience conducting HEOR research
At least 5 years of relevant experience (or 10 years with MS degree) conducting HEOR research across methodologies such as SLR, ITC/NMA/MAIC/STC, CEA/BIA models, RWE designs, and PRO analytics
Expertise in US/Ex-US real-world data sources (e.g., Komodo, Optum, Medicare RIF) with proficiency in study design evaluation and improvement
Deep understanding of EU-HTA requirements including JSC/EA/JCA implementation alongside knowledge of global health technology assessment guidelines
Excellent communication skills with experience presenting HEOR research to payers/population health decision-makers

Nice To Haves

Experience with eCOA implementation preferred; familiarity with FDA COA Type C meetings and negotiating PRO label claims a plus
Proven track record of peer-reviewed publications showcasing HEOR expertise across multiple domains

Responsibilities

Develop and execute Global value evidence generation plans for systematic literature reviews (SLR), indirect treatment comparisons (ITC), cost-effectiveness analyses (CEA), budget impact analyses (BIA), real-world evidence (RWE), and patient-reported outcomes (PRO) to optimize clinical development decisions across all stages of drug development
Conduct global epidemiology literature reviews to inform multi-regional clinical trial site selection and recruitment strategies
Provide guidance on FDA regulations related to patient-reported outcomes (PROs) and patient-focused drug development (PFDD), ensuring alignment with labeling claims
Prepare regulatory-grade documents such as FDA/Global Regulatory briefing books for PRO Endpoint implementation, epidemiology, and pediatric investigation plans
Lead the implementation of robust evidence synthesis strategies to support global pharmaceutical launches and reimbursement dossiers across HTA markets & Non HTA Markets like PICOS Simulation/Scoping, PICOS feasibility assessment and development JCA dossiers
Lead the development of early advice (EA) dossiers (Country level and JSC) and actively participate in discussion with relevant stakeholders on the value of the clinical program. Stay at the forefront of industry trends and integrate emerging methodologies into evidence synthesis plans including the use of AI in SLR/ITCs/ RWE and Global Value Evidence tool kit development
Collaborate with key opinion leaders, including medical experts, through structured engagements like advisory boards and Delphi panels
Develop pre-approval dossiers, launch models (CEA/BIA), tools, relevant Health Care Economic Information (HCEI) training materials to support US Account Management teams, Medical Science Liaisons, and field-based HEOR professionals
Support other HEOR team members by reviewing their evidence generation plans, publications and offering constructive- solution oriented feedback.
Mentor HEOR fellows and early-career team members while providing constructive feedback on evidence generation plans

Benefits

Medical, Dental and Vision Insurance
Life, AD&D, Critical Illness Insurance
Pre-tax HSA & FSA, DCRA Spending Accounts
Employee Assistance & Concierge Program (EAP) available 24/7
Parental and Childbirth Leave & Family Planning Assistance
Sitterstream: Virtual Tutoring & Childcare Membership
Paid Time Off: Vacation, Sick, Bereavement, Holidays (including Floating) & Year-End U.S. Shutdown.
401(K) Plan with Company Match
Tuition Reimbursement & Student Loan Assistance Programs
Wellbeing Incentive Platforms & Incentives
Professional Development Programs
Commuting Allowance and subsidized parking
Discounted Home, Auto & Pet Insurance