Experienced Scientist II

Johnson & Johnson•San Diego, CA

28d•Onsite

About The Position

RNA Therapeutics and Delivery is an organization within Therapeutics Discovery, committed to the delivery of high-quality drug candidates in the novel synthetic modalities space working closely with Johnson & Johnson Innovative Medicines Therapeutic Areas (TA) discovery teams. Our mission requires critical thinking, a portfolio approach and deep scientific expertise in several fields including oligonucleotide chemistry, bioconjugation chemistry, nanotechnology, cellular and molecular pharmacology and screening technologies coupled with an ability to work collaboratively with internal and external partners. This role offers growth opportunity within a dynamic and science driven organization. About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com/ . Our mission requires critical thinking, a portfolio approach and deep scientific expertise in several fields including oligonucleotide chemistry, bioconjugation chemistry, nanotechnology, cellular and molecular pharmacology and screening technologies coupled with an ability to work collaboratively with internal and external partners. This role offers growth opportunity within a dynamic and science driven organization.

Requirements

Analytical Reasoning
Assay Development
Chemistry
Collaborating
Data Analysis
Data Compilation
Drug Discovery Development
Innovation
Interdisciplinary Work
Organizing
Quantitative Research
Research Ethics
Research Informatics
Scientific Evaluation
Scientific Research
Technologically Savvy

Nice To Haves

Machine Learning (ML)

Responsibilities

Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects
Optimize methods and improve analytical capabilities for novel Oligonucleotide synthesis
Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS.
Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput.
Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography.
Continue optimizing siRNAs using best-in class analytical chemistry methodologies such as different column matrixes for optimal siRNA characterization
Support integrity confirmation requests (such as concentration) by assay development and biology teams
Conduct QC for lipid nanoparticle (LNP) formulations of mRNA
Ensure the supply of laboratory consumables and reagents are in stock as needed
Maintain a high level of productivity in the laboratory setting.
Present data and reports on project status at individual, group, and departmental meetings.

Benefits

Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).
This position is eligible to participate in the Company’s long-term incentive program.
Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits:
Vacation –120 hours per calendar year
Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year
Holiday pay, including Floating Holidays –13 days per calendar year
Work, Personal and Family Time - up to 40 hours per calendar year
Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
Caregiver Leave – 80 hours in a 52-week rolling period10 days
Volunteer Leave – 32 hours per calendar year
Military Spouse Time-Off – 80 hours per calendar year
For additional general information on Company benefits, please go to: - https://www.careers.jnj.com/employee-benefits