Director, Program Management

Septerna•South San Francisco, CA

6h•Onsite

About The Position

We are seeking an experienced Director of Program Management to join our dynamic team. This role will be critical in driving programs from discovery and development candidate nomination through clinical development, ensuring high-quality, decision-ready execution across research, preclinical, regulatory, and clinical functions. In this role, you will provide end-to-end program management leadership, serving as the operational owner for assigned programs. You will be accountable for integrated program plans, timelines, risk management, and governance, and will partner closely with scientific and development leaders to align execution with company strategy. As the point of contact for program execution, you will proactively manage risks, facilitate trade-off discussions, and enable informed decision-making at both the team and executive levels. This position reports to the Senior Director of Program and Portfolio Management and is a full-time, onsite position requiring in-person collaboration with cross-functional teams.

Requirements

Advanced degree relevant to drug discovery/development; Ph.D./ PharmD/MBA preferred
Minimum of at least 10-15+ years of experience within the Biotech or Pharma industry; prior experience in project management required, specifically in the early clinical development space
Proven expertise in project planning, execution, and risk management, with a deep understanding of drug development processes, particularly in endocrinology, immunology, CNS
Demonstrated track record of managing small molecule discovery projects from early research through development candidates and IND/CTA submissions, clinical trial management, and program strategy development
Experience with commonly used project management tools, including Microsoft Project and Smartsheet
Ability to execute diverse and novel strategies in a matrix environment; experience managing and influencing complex issues and a variety of key stakeholders
Demonstrated skill in driving execution and focusing on deliverables
Strong organizational skills, persistent attention to detail, and ability to work independently and collaboratively to manage timelines and priorities
Ability to manage complex situations and adapt to changing business needs by prioritizing multiple tasks
Strong interpersonal and communication skills. Demonstrated ability to collaborate closely with individual project leads/teams and scientific leadership
Desire to work on a small team in a fast-paced environment

Responsibilities

Lead program management for one or more development programs from preclinical development through clinical stages
Partner with the cross-functional Product Development Team to define program strategy, conduct scenario planning, and translate strategy into executable plans to achieve program objectives
Identify and manage program-level risks, assumptions, and interdependencies; lead mitigation planning and issue resolution
Escalate risks and decision points with clear options and recommendations
Work with teams to prepare presentations for internal and external meetings (e.g., team presentations, management review, Board of Directors meetings)
Develop and maintain integrated program plans, including milestones, timelines, budgets, and resource assumptions
Monitor progress against plans, identify deviations, and implement mitigation strategies or alternative scenarios
Conduct critical path and dependency analyses to proactively identify risks and bottlenecks
Ensure clear, consistent, and transparent communication of program status, key risks, and upcoming milestones
Align diverse stakeholders around priorities, decisions, and execution plans in a matrixed environment
Contribute to the design, implementation, and continuous improvement of program management processes, tools, and templates
Promote best practices in program planning, governance, and execution across the organization