Director, Precision Medicine

Day One Biopharmaceuticals•Brisbane, CA

2d•$215,000 - $230,000•Remote

About The Position

At Day One, we are focused on advancing first- or best-in-class medicines for childhood and adult diseases with equal intensity. We were founded to address the lack of new therapies resulting from the traditional drug development model, that has left children with cancer and their families waiting too long for new, life-changing treatments. Our aim is to accelerate better, targeted treatments so patients of any age can look forward from ‘day one’ to the future they’ve envisioned. POSITION SUMMARY: Day One Biopharmaceuticals is seeking a creative, intelligent, deeply committed, high-integrity, scientific leader to develop and maintain precision medicine vision and strategy and provide expertise in clinical diagnostics across our portfolio of targeted therapeutics for children and adults with cancer. In conjunction with senior leaders in Clinical Development, Translational and Precision Medicine, Regulatory Sciences and supported by a deeply experienced cross-functional team of experts in drug development, you will be responsible for ensuring the consistent application of precision medicine and diagnostics across all stages of clinical development. This individual will be a key member of the Translational and Precision Medicine Team within our Research and Development organization and will report to our Head of Precision Medicine. This role is expected to be a precision medicine functional lead on product teams with influence across all programs, though initially operating as a hands-on individual contributor. This position has the potential to be fully remote. Occasional travel will be required for in-person meetings.

Requirements

Bachelor’s degree (PhD or MD/PhD preferred) in biology, immunology, chemistry, pharmacology, biochemistry, or related discipline
10+ years’ experience in commercial diagnostic testing and/or oncology drug discovery/development setting within the biopharmaceutical industry (biotech or large pharma). A diverse background across assay, diagnostics, cancer biology, and drug development is required with relevant expertise in the interpretation of clinical molecular diagnostic testing reports, and understanding of clinical biomarkers and Companion Diagnostics development strategy and execution is strongly desired
Ability to interpret complex molecular and clinical datasets and translate insights into program strategy
Unwavering integrity and trustworthiness, embodying Day One’s core values
Eloquent and passionate when talking about science and the potential to help patients
Keen scientific acumen and intellectual curiosity, good judgement, and the highest scientific integrity
Curious, creative with an ability to think outside of traditional drug development and corporate models
A team player and a mentor – someone who cares for their colleagues as people as well as contributors and collaborators, while delivering results
Inspires the confidence of others, and inspires others to fulfill their potential
The ability to elicit and synthesize information from a range of individuals and sources rapidly and clearly communicate findings across the organization
Start-up/small biotech experience is strongly preferred or a clear desire to dive into working with a small team.

Nice To Haves

Pediatric oncology and/or rare disease experiences are highly desirable

Responsibilities

Develop and maintain precision medicine vision and strategy through cross-functional partnership with Leadership of Clinical Development, Translational Research, Regulatory Sciences, Clinical Pharmacology, and Commercial, as well as other Day One functions
Design and implement hypothesis-driven strategies to deliver evidence of target engagement, mechanisms of action/resistance, patient selection/CDx strategies and other clinically-relevant biomarker endpoints to advance the Day One pipeline
Provide technical, clinical and regulatory expertise in assay development and diagnostics (NGS, IHC, Immunoassays along with emerging biomarker technologies and platforms) across diverse stakeholders comprising leadership in Research and Development, Commercial, Regulatory Sciences, Medical Affairs, and Patient Advocacy, including but not limited to, training, education, and representation on behalf of our Translational and Precision Medicine-related events
Effectively partner with Precision Medicine leaders to execute on the development of clinical biomarkers, assay development through companion diagnostics to maximize patient access to Day One drugs
Manage external diagnostic partners, CROs, academic collaborators, and vendors to ensure high-quality biomarker and CDx deliverables.
Leadership expertise in developing and maintaining precision medicine screening strategies across clinical programs, leveraging your extensive experience in testing report interpretation
Author and review Precision Medicine related publications as well as appropriate sections in clinical study / regulatory documents (i.e. INDs, IBs, trial protocols/ops manuals, ICFs, IRB responses, HA Briefing Books, CSRs, etc.)
Work closely with Business Development and Precision Medicine leaders to support candidate asset acquisition assessments through clinical biomarker and CDx considerations
Develop and implement comprehensive clinical biomarker strategy across clinical programs
Lead the strategic planning and execution of CDx development, including assay selection, analytical validation strategies, clinical validation plans, and alignment with regulatory and commercial partners.
Help Day One remain a leader in oncology drug development across all ages
Engaging, inspiring, and successfully communicating with employees of any level in the organization.
Understanding and embracing one of our highest values: that the most precious asset is our team.
Proactively contributing to company-building and process evolution as we grow