Director of Epidemiology, Medical Evidence Generation

Ionis•Carlsbad, CA

13d•$240,000 - $260,000•Hybrid

About The Position

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals. At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career! DIRECTOR OF EPIDEMIOLOGY, MEDICAL EVIDENCE GENERATION SUMMARY: The Director of Epidemiology is part of the Medical Evidence Generation (MEG) team and will serve as the lead for the Medical Affairs Epidemiology function, serving as a cross-TA epidemiology resource. The Director of Epidemiology provides scientific and strategic leadership for epidemiology activities across the product lifecycle in 20-30 different disease states, working closely with cross-functional teams including Medical Affairs, Clinical Development, HEOR, and Commercial teams. The Director of Epidemiology will provide epidemiology expertise and will design and conduct epidemiology studies/analyses and literature reviews to support organizational needs for epidemiology information across Ionis’ product portfolio and pipeline. This role will report to the Executive Director of Medical Evidence Generation.

Requirements

A PhD or Master’s degree in epidemiology, public health, or related field with at least 8 years of experience (PhD level) or 12 years of experience (Master’s level) in Epidemiology and/or Evidence Generation in the pharmaceutical industry.
Demonstrated experience leading epidemiologic studies across multiple phases of the product lifecycle and in rare diseases.
Strong knowledge of observational study designs, pharmacoepidemiology, genetic epidemiology, and real-world data sources (e.g., claims, EHRs, registries).
Understanding of statistical methods for epidemiologic research
Strong analytical and problem-solving skills.
Strong publication record.
Experience in creation and management of a disease state epidemiology database.
Excellent verbal and written communication and presentation skills.
Ability to work collaboratively with cross-functional teams.
Ability to lead without authority, specifically working with other functions to reach agreement
Ability to work independently and manage multiple projects simultaneously.
If you are passionate about using epidemiology methods to improve health outcomes for patients and have appropriate qualifications, we encourage you to apply for this exciting opportunity.

Responsibilities

Serve as the principal epidemiology expert and resource for the organization.
Responsible for the epidemiological approach and standards (governance, methodological guidance, quality expectations, and “source of truth” stewardship).
Assess the long-term strategic impact of epidemiology information across the enterprise, as well as from individual functional perspectives.
Serve as the hub of epidemiology data (cross-TA) for internal and external use, based on literature reviews or other sources.
Maintain a database of all approved epidemiology estimates for disease states.
Lead the design, execution, and interpretation of epidemiologic studies.
Lead alignment with Medical Evidence Generation TA leads to ensure epidemiology activities are aligned with evidence strategy.
Lead cross-functional teams including Medical Affairs, Clinical Development, HEOR, Corporate Communications, Investor Relations, and Commercial teams to ensure that epidemiology estimates are aligned with the overall business objectives.
Review and approve study protocols, analysis plans, study reports, and manuscripts.
Present epidemiology study results to internal and external stakeholders, including at scientific conferences, and other relevant forums.
Stay up-to-date with the latest developments in epidemiology, observational research, registry methodologies, Phase 4 study design, and advanced analytical methods, and incorporate them in Ionis’ medical evidence generation activities.