Director, New Product Commercialization, New Wave

Alnylam Pharmaceuticals • Cambridge, MA

8d

About The Position

We are seeking a strategic and analytically rigorous Director, New Product Commercialization, Next Wave, to lead the evaluation of commercial potential for our early-stage pipeline assets. This role sits at the intersection of R&D and commercial strategy and will play a pivotal role in shaping portfolio priorities, guiding clinical development strategies, and maximizing the long-term value of our drug candidates.

Requirements

• Bachelor’s degree required; advanced degree preferred (MBA, PhD, PharmD, or MD)
• 10+ years of experience in biotech/pharma, with a strong focus on commercial strategy, new product planning, or consulting
• Demonstrated experience supporting drug development decisions (preclinical through Phase 3)
• Strong strategic thinking and ability to connect clinical data to commercial outcomes
• Deep understanding of drug development, market access, and healthcare ecosystems
• Advanced analytical and financial modeling skills (forecasting, valuation)
• Excellent communication and storytelling skills, with the ability to influence senior leaders
• Experience working in cross-functional, matrixed environments
• Highly collaborative with strong stakeholder management skills
• Comfortable with ambiguity and able to operate in early-stage environments
• Action-oriented with a strong sense of ownership and accountability
• Curious, insightful, and driven by impact

Responsibilities

• Drug Candidate Asset Evaluation
• Conduct drug candidate asset and indication evaluations -- lead development of preliminary TPPs and differentiation hypothesis with cross functional team
• Evaluate market opportunity, unmet need, patient segmentation, and treatment paradigms
• Translate clinical data into clear commercial implications and strategic recommendations
• Identify key value drivers, risks, and “make-or-break” assumptions for each asset
• Market & Competitive Intelligence
• Conduct deep competitive landscape assessments, including pipeline tracking and benchmarking
• Monitor evolving standard of care, pricing dynamics, and access considerations across key markets
• Synthesize primary and secondary market research into actionable insights
• Evidence & Development Strategy Input
• Provide commercial input into clinical trial design (endpoints, comparators, patient populations)
• Identify evidence gaps required to support future pricing, reimbursement, and differentiation
• Ensure alignment between clinical development plans and future market access needs
• Lead without formal authority
• Manage external partners that support asset evaluation; serve as conduit between internal program teams and analytic partners
• Comfortable building from scratch (frameworks, models, narratives)
• Act as a key commercial voice within cross-functional asset teams
• Influence senior stakeholders and executive leadership with clear, data-driven recommendations

Benefits

• comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match
• Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks
• We also offer generous family resources and leave

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Number of Employees: 501-1,000 employees