Director, Medical Affairs Strategy and Operations

Alnylam Pharmaceuticals

About The Position

The Director, US Medical Strategy and Excellence is a senior leadership role responsible for shaping and driving the strategic medical planning process across the U.S. TTR Medical Affairs organization. This role serves as a core member of the U.S. Medical Leadership Team and plays a critical role in ensuring strong alignment across U.S. Medical, Commercial, Global Medical Excellence, and Analytics and Insights (CC&I). The Director will lead U.S. medical excellence initiatives, advance key medical capabilities, and design and execute pilots that elevate how Medical Affairs delivers evidence-based, patient-centric impact. This role requires both strategic vision and operational rigor, with accountability for end-to-end execution of priority initiatives.

Requirements

Advanced degree required (PharmD, MD, PhD, or equivalent scientific degree)
Significant experience in Medical Affairs with demonstrated leadership in strategy, planning, and execution
Proven ability to operate effectively in complex, matrixed organizations
Strong strategic thinking combined with operational discipline and follow-through

Nice To Haves

Experience spanning pharmaceutical, medical technology, and biotechnology organizations
Prior experience in in-house Medical Director roles with accountability for medical strategy and execution
Direct experience in Field Medical roles, including MSL positions, with strong understanding of scientific exchange and insight generation
Experience leading Field Medical teams or Field Medical Excellence functions
Demonstrated success partnering with commercial, global medical, and analytics teams
Strong executive presence, communication skills, and ability to influence senior stakeholders

Responsibilities

Lead the U.S. Medical strategic planning process, including annual and multi-year medical plans aligned to brand strategy and enterprise priorities
Translate global medical strategy into U.S.-specific plans that are actionable, measurable, and scalable
Partner closely with U.S. Medical leadership to ensure strategic priorities are clearly defined, resourced, and executed
Lead U.S. Medical Excellence, including the design, implementation, and continuous improvement of medical capabilities, processes, and ways of working
Identify, pilot, and scale innovative approaches that enhance scientific exchange, insight generation, and medical impact
Ensure alignment with Global Medical Excellence frameworks while tailoring execution to U.S. needs
Serve as a key integrator across U.S. Medical, U.S. Commercial, Global Medical, and CC&I to ensure alignment on priorities, insights, and execution
Partner with CC&I to operationalize analytics, dashboards, and insights that inform strategy, measure impact, and drive decision-making
Ensure medical insights are systematically captured, synthesized, and shared to inform broader TTR strategy
Own end-to-end execution of key U.S. Medical initiatives, from strategy through implementation and impact assessment
Establish clear governance, milestones, and accountability to ensure consistent delivery of high-priority programs
Monitor progress, identify risks, and course-correct as needed to ensure excellence in execution
Act as a core member of the U.S. Medical Leadership Team, contributing to enterprise-level thinking and decision-making
Influence without authority across matrixed teams and stakeholders
Model a culture of accountability, rigor, collaboration, and continuous improvement

Benefits

comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match
Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks
We also offer generous family resources and leave

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