Director In Vivo Gene Therapy Core

Guidehouse•Bethesda, MD

7d•$171,000 - $285,000•Onsite

About The Position

We are currently searching for Director of the In Vivo Gene Therapy Core to lead the development and implementation of a strategic resource supporting in vivo gene therapy across the National Heart, Lung, and Blood Institute (NHLBI) Division of Intramural Research. This is a full-time, on-site opportunity in Bethesda, MD. Lead the development and implementation of a strategic resource supporting in vivo gene therapy across the NHLBI Division of Intramural Research. Accelerate the development of novel delivery systems—including lipid nanoparticles, viral vectors, and other technologies—for treating heart, lung, blood, autoimmune, sleep and rare diseases. Provide scientific and operational leadership. Establish and refine laboratory and clinical manufacturing workflows. Oversee a multidisciplinary team of scientific and technical staff. Shape the scientific direction of the Core. Ensure quality control and operational readiness. Provide expert guidance on platform refinement. Work closely with NHLBI investigators to support early ligand screening, preclinical model evaluation, and IND-enabling studies. Managing daily operations. Collaborate with the Steering Committee to guide project intake, review feasibility, and advise on scientific direction and resource planning. Build strategic collaborations across the NIH and with academic, clinical, and industry partners.

Requirements

PhD, MD, or equivalent doctoral degree with a minimum of Ten (10) years of combined education and relevant experience, including at least FIVE (5) years of hands‑on experience in in vivo gene therapy, therapeutic delivery systems, translational research, or related specialties.
Experience with preclinical models, GLP/GMP-compliant workflows, and regulatory engagement.
Strong record of scientific innovation, proven leadership in complex research environments, and a collaborative, solutions-oriented approach to advancing translational gene therapy.

Nice To Haves

Ability to collaborate with stakeholders from diverse backgrounds.
Strong written and oral communication skills.
Publications in peer reviewed journals.

Responsibilities

Lead the development and implementation of a strategic resource supporting in vivo gene therapy across the NHLBI Division of Intramural Research.
Accelerate the development of novel delivery systems—including lipid nanoparticles, viral vectors, and other technologies—for treating heart, lung, blood, autoimmune, sleep and rare diseases.
Provide scientific and operational leadership.
Establish and refine laboratory and clinical manufacturing workflows.
Oversee a multidisciplinary team of scientific and technical staff.
Shape the scientific direction of the Core.
Ensure quality control and operational readiness.
Provide expert guidance on platform refinement.
Work closely with NHLBI investigators to support early ligand screening, preclinical model evaluation, and IND-enabling studies.
Managing daily operations.
Collaborate with the Steering Committee to guide project intake, review feasibility, and advise on scientific direction and resource planning.
Build strategic collaborations across the NIH and with academic, clinical, and industry partners.

Benefits

Medical, Rx, Dental & Vision Insurance
Personal and Family Sick Time & Company Paid Holidays
Parental Leave
401(k) Retirement Plan
Group Term Life and Travel Assistance
Voluntary Life and AD&D Insurance
Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
Transit and Parking Commuter Benefits
Short-Term & Long-Term Disability
Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
Employee Referral Program
Corporate Sponsored Events & Community Outreach
Care.com annual membership
Employee Assistance Program
Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)