Director, In Vivo Research

Insmed Incorporated

4d • Onsite

About The Position

At Insmed, every moment and every patient counts — and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you’ll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person’s contributions to meaningful progress. That commitment has earned us recognition as Science magazine’s No. 1 Top Employer for five consecutive years, certification as a Great Place to Work® in the U.S., and a place on The Sunday Times Best Places to Work list in the UK. For patients, for each other, and for the future of science, we’re in. Are you? About the Role: We’re looking for an exceptionally self-motivated, intellectually curious, and entrepreneurially minded Director, In Vivo Research with deep expertise in translational research for Insmed’s New Jersey Research Team to help us expand what’s possible for patients with serious and rare diseases. Reporting to the Senior Director of Research, you will lead rodent disease model development and the design and execution of preclinical in vivo studies and will collaborate closely with peers across the research organization to drive Insmed’s pipeline programs from discovery towards IND.

Requirements

• Ph.D. degree in Life sciences discipline with deep in vivo pharmacology background and 10+ years of industry experience, including leadership responsibility
• Demonstrated success leading in vivo pharmacology strategy for both small molecule entities and biologics
• Extensive experience proposing, developing, establishing, and evaluating fit-for-purpose in vivo models including but not limited to genetically modified mouse strains and disease models in the immunology, respiratory, and CNS space
• Strong understanding of PK/PD principles and translational considerations that inform candidate selection and program progression
• Expert hands-on knowledge in standard dosing and fluid collection techniques and conducting survival surgery in rodents
• Strong familiarity with IACUC protocols and compliance with ethical and regulatory standards for animal research
• Demonstrated experience managing projects and leading teams in the context of multiple competing priorities and tight deadlines
• Experience collaborating and communicating effectively to optimally support functional and cross-functional operations
• Strategic thinker with an entrepreneurial mindset, proactive problem-solving attitude and strong willingness to take on new challenges
• High level of organization with a strong attention to detail, clarity, accuracy and conciseness
• Thrives in a dynamic, fast-paced research environment and is comfortable making decisions with evolving data

Nice To Haves

• Hands-on expertise in CNS/brain delivery

Responsibilities

• Provide strategic leadership for the in vivo pharmacology function to enable Insmed’s early-stage research pipeline and advance innovative therapies to the clinic.
• Identify, validate, and implement appropriate PK/PD models to support candidate selection
• Develop and execute in vivo pharmacology strategies for efficacy, PK/PD, biodistribution, and safety evaluations in rodents
• Contribute to the strategic vision for PK/PD and in vivo pharmacology to support portfolio and candidate selection decisions across early research programs
• Lead, develop, and build a team of in vivo scientists
• Partner closely with cross-functional teams to support in vivo pharmacology needs and integrate with toxicology and translational strategies
• Review, interpret, and communicate complex data to internal stakeholders and senior leadership
• Author and review protocols, electronic notebook entries, technical reports, and scientific publications
• Provide oversight and scientific input for pharmacology studies conducted by CROs and academic partners
• Contribute to external scientific presence, including authorship and review of publications, abstracts, and presentations, as appropriate
• Ensure compliance and best practice related to IACUC protocols and all relevant regulatory and ethical standards for animal research

Benefits

• Comprehensive medical, dental, and vision coverage and mental health support, annual wellbeing reimbursement, and access to our Employee Assistance Program (EAP)
• Generous paid time off policies, fertility and family-forming benefits, caregiver support, and flexible work schedules with purposeful in-person collaboration
• 401(k) plan with a competitive company match, annual equity awards, and participation in our Employee Stock Purchase Plan (ESPP), and company-paid life and disability insurance
• Company Learning Institute providing access to LinkedIn Learning, skill building workshops, leadership programs, mentorship connections, and networking opportunities
• Employee resource groups, service and recognition programs, and meaningful opportunities to connect, volunteer, and give back

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree