Dir/Sr Director, Medicinal Chemistry

Iambic Therapeutics•San Diego, CA

39d•$192,000 - $255,000•Onsite

About The Position

Iambic Therapeutics is seeking an experienced and creative medicinal chemist with a proven track record of success in drug discovery. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team-based setting. The role will entail coordinating a medicinal chemistry team with internal and external experimental capabilities, as well as proactively interfacing with diverse teams working on automated experimentation, ML-driven molecular generation, property predictions, and bioassay data generation. This position is located at our San Diego Headquarters.

Requirements

Ph.D. in Organic Chemistry with 15+ years or Masters with 18+ years of Pharma/bio-tech drug discovery experience or (portfolio of programs from hit/lead to development candidate)
Expertise in modern synthetic organic chemistry, evidenced by high-quality publications and patents.
Proven cross-functional leadership: integrating biology, DMPK/ADME, CADD, and CMC to build and execute strategic project plans.
Practical experience and working knowledge of target protein degradation and associated modalities (molecular glues, PROTACS).
Track record of program leadership advancing compounds through preclinical development (candidate nomination, IND-enabling interfaces, CRO oversight).
Experience working with computational chemists as part of project team in design of drug targets is required.
Strong interpersonal, communication, time management, and leadership skills.
Experience mentoring or leading junior chemists.
Creative problem solving and management of relationships with several stakeholders within and beyond the company.

Responsibilities

Lead a group of medicinal chemists and drive molecular discovery efforts to deliver development and clinical candidates.
Devise strategies to execute hit ID, identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis driven design principles.
Work closely with molecular and cellular biology, pharmacology, computational chemistry, DMPK, and other key functions.
Act as a liaison between Iambic, CROs, and other external collaborators, including partnered research projects.
Influence the prospective use of computational methods and leverage automated synthesis and high-throughput experimentation capabilities.
Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules.
Contribute to platform development by collaborating with AI/ML and chemistry automation teams to enhance processes and accelerate the design-make-test (DMT) cycle.
Communicate project updates clearly and effectively to the broader team and key stakeholders.
Work as a senior member of the Chemistry research group and foster a culture of scientific excellence, innovation, and teamwork.