Contract, Drug Metabolism and Pharmacokinetics (DMPK)

PTC Therapeutics, Inc. • Bridgewater, NJ

30d • $45 - $70 • Onsite

About The Position

PTC Therapeutics is a global commercial biopharmaceutical company. For over 25 years our team has been deeply committed to a unified purpose: Extending life’s moments for children and adults living with a rare disease. At PTC, we cultivate an inclusive culture where everyone feels valued, respected, and empowered. We welcome candidates from all backgrounds to join our team, fostering a strong sense of belonging. Visit our website to learn more about our company and culture! Site: www.ptcbio.com Job Description Summary: The Contract, Drug Metabolism and Pharmacokinetics (DMPK) plans and performs in vitro and in vivo metabolism/bioanalysis assays in support of DMPK studies in discovery and early development. The Contract, DMPK interprets data and communicates experimental results to his/her supervisor and colleagues. The incumbent works cross-functionally with internal departments, and external resources as appropriate, as part of PTC’s discovery science project teams. The Contract, DMPK supports adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as appropriate. . Job Description: ESSENTIAL FUNCTIONS Primary duties/responsibilities: With guidance, initiates and executes scientific research and experiments and interprets and communicates results as part of multi-disciplinary team(s). Performs and maintains established in vitro and in vivo metabolism/bioanalysis assays. With guidance, develops new, and improves upon existing DMPK assays. Performs hands-on in vitro and in vivo metabolism/bioanalysis assays using LC-MS/MS. Documents experiment details in lab books, records results in database and prepares study reports. Abides by all safety and regulatory guidelines. Performs other tasks and assignments as needed or specified by management. Contributes to general lab needs such as: Equipment maintenance and/or troubleshooting. Capital equipment purchases.

Requirements

• A Master’s degree in Biology, Chemistry, Biochemistry, Pharmaceutical Science, Pharmacology or other related scientific discipline and a minimum of 2 years of relevant and progressively responsible experience in a pharmaceutical, biotechnology or similar environment OR a Bachelor’s degree in these same disciplines and a minimum of 4 years of the same experience.
• Demonstrated experience in conducting in vitro and in vivo DMPK studies, such as metabolic stability in liver microsomes and hepatocytes, CYP inhibition and induction, and bioanalysis in various matrices etc.
• Demonstrated experience in operating and troubleshooting contemporary LC-MS instruments and automated liquid handlers.
• Hands-on experience with liquid handlers, LC-MS instruments and other equipment.
• Detailed knowledge of DMPK and applied techniques.
• Experience with developing and optimizing relevant DMPK assays.
• Ability to work independently and collaboratively, as required, in a fast-paced, matrixed, team environment that may consist of both internal and external team members.
• Proficiency with Microsoft Office.
• Good verbal and written communication skills.
• Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines.
• Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects

Nice To Haves

• Knowledge of drug metabolism and pharmacokinetics in discovery preclinical research.

Responsibilities

• With guidance, initiates and executes scientific research and experiments and interprets and communicates results as part of multi-disciplinary team(s).
• Performs and maintains established in vitro and in vivo metabolism/bioanalysis assays.
• With guidance, develops new, and improves upon existing DMPK assays.
• Performs hands-on in vitro and in vivo metabolism/bioanalysis assays using LC-MS/MS.
• Documents experiment details in lab books, records results in database and prepares study reports.
• Abides by all safety and regulatory guidelines.
• Performs other tasks and assignments as needed or specified by management.
• Contributes to general lab needs such as: Equipment maintenance and/or troubleshooting. Capital equipment purchases.

What This Job Offers

• Career Level: Mid Level