Clinical Genomics Variant Analysis Director - Invitae - Remote

Labcorp • Denver, CO

3d • Remote

About The Position

Labcorp is seeking a US remote-based Variant Analysis Director to join its team. Responsibilities: Provide strategic, technical, and operational leadership for clinical interpretation and reporting activities across core technologies including whole genome sequencing (WGS), whole exome sequencing (WES), targeted NGS panels, and chromosomal microarray (CMA) Serve as a subject matter expert in genomic testing workflows, interpretation frameworks, and clinical reporting standards, ensuring scientific rigor, clinical relevance, and regulatory compliance Oversee day-to-day operational performance, including production scheduling, capacity planning, process health monitoring, and escalation of operational incidents Establish, optimize, and scale end-to-end workflows for clinical interpretation and reporting, applying continuous improvement methodologies to improve efficiency, quality, and throughput Define, implement, and monitor key operational metrics to assess performance, identify risk, and communicate status, trends, and opportunities to senior leadership Ensure delivery of high-quality clinical reports that meet established turnaround time, accuracy, and quality benchmarks Lead diagnosis and resolution of complex production issues, driving root-cause analysis and implementation of sustainable corrective and preventive actions Develop and execute operational strategies and goals aligned with broader organizational objectives and key results Act as an individual-contributor Director with significant strategic and operational scope, with the expectation of evolving people leadership responsibilities as the organization scales Mentor and coach scientists, genetic counselors, and operational partners, fostering a culture of continuous learning, accountability, and scientific excellence Collaborate cross-functionally with Laboratory, Bioinformatics, Product, Quality, Regulatory, IT, and Clinical Development teams to support successful launch of new assays, tools, and initiatives Provide input into strategic planning, organizational design, and capacity modeling through data-driven insights Foster a culture of operational excellence, best practices, and professional growth Perform other duties as assigned in support of departmental and company goals

Requirements

• PhD in Biological Sciences, Molecular Genetics, Human Genetics, or a related field, with a minimum of 5 years of related work experience; or Master’s degree in Genetic Counseling, Biological Sciences, Molecular Genetics, Human Genetics, or a related field, with a minimum of 6 years of related work experience; or Bachelor’s degree in Genetics, Biological Sciences, Molecular Genetics, Human Genetics, or a related field, with a minimum of 7 years of related work experience
• 5 years of experience in operational leadership, including managing a team, workflow optimization, capacity planning, performance metrics, and cross-functional execution
• Clinical genomics or molecular diagnostics experience in a CLIA-certified or similarly regulated laboratory environment
• Variant interpretation, curation, and clinical reporting for NGS-based assays, including WGS, WES, and/or targeted panels
• Operational leadership supporting clinical interpretation or reporting workflows, including capacity planning, quality management, and process optimization
• Cross-functional collaboration with laboratory, bioinformatics, product, quality, regulatory, or clinical development teams
• Experience supporting the development, launch, or scaling of clinical genomic assays or interpretation programs
• Demonstrated ability to independently lead complex initiatives and influence outcomes without direct people management responsibility
• Strong understanding of clinical reporting operations, quality systems, and regulated laboratory environments (e.g., CLIA, CAP)
• Proven ability to operate at a Director level, balancing strategic planning with hands-on operational leadership
• Strong analytical, problem-solving, and communication skills, with the ability to translate technical and operational data into executive-level insights
• Demonstrated technical expertise with whole genome sequencing (WGS) and whole exome sequencing (WES), including strong understanding of clinical interpretation frameworks, reporting standards, and end-to-end workflows
• Excellent written, verbal, and interpersonal communication skills
• Ability to follow standard operating procedures with accuracy and attention to detail
• Ability to adapt to significant change that is inherent in development and innovation
• Desire to work in and contribute to a fast-paced, highly collaborative environment
• Demonstrated ability to understand, synthesize, and coherently evaluate complex genetic information

Nice To Haves

• Lean Six Sigma certification (Green Belt or higher) or demonstrated experience applying Lean, Six Sigma, or similar continuous improvement methodologies in a scaled operational environment preferred
• Director-level experience within a CLIA-certified diagnostic laboratory or similarly regulated clinical setting preferred
• Deep familiarity with next-generation sequencing technologies and clinical interpretation frameworks, including variant curation and assessment of clinical relevance preferred
• Knowledge of advanced copy number detection methodologies and copy number variant (CNV) interpretation across CMA and NGS-based platforms preferred
• Experience with rapid or NICU whole genome sequencing (NICU WGS), including high-acuity clinical workflows, expedited turnaround requirements, and cross-functional coordination preferred
• Experience or strong interest in one or more clinical domains, including oncology, cardiology, neurology, carrier screening, metabolic disorders, pediatric diagnostics, cytogenomics, and/or exome analysis preferred
• Demonstrated experience scaling clinical interpretation or reporting operations in a high-throughput, regulated environment preferred
• Knowledge of advanced copy number detection methodologies and copy number variant (CNV) interpretation across CMA and NGS-based platforms preferred

Responsibilities

• Provide strategic, technical, and operational leadership for clinical interpretation and reporting activities across core technologies including whole genome sequencing (WGS), whole exome sequencing (WES), targeted NGS panels, and chromosomal microarray (CMA)
• Serve as a subject matter expert in genomic testing workflows, interpretation frameworks, and clinical reporting standards, ensuring scientific rigor, clinical relevance, and regulatory compliance
• Oversee day-to-day operational performance, including production scheduling, capacity planning, process health monitoring, and escalation of operational incidents
• Establish, optimize, and scale end-to-end workflows for clinical interpretation and reporting, applying continuous improvement methodologies to improve efficiency, quality, and throughput
• Define, implement, and monitor key operational metrics to assess performance, identify risk, and communicate status, trends, and opportunities to senior leadership
• Ensure delivery of high-quality clinical reports that meet established turnaround time, accuracy, and quality benchmarks
• Lead diagnosis and resolution of complex production issues, driving root-cause analysis and implementation of sustainable corrective and preventive actions
• Develop and execute operational strategies and goals aligned with broader organizational objectives and key results
• Act as an individual-contributor Director with significant strategic and operational scope, with the expectation of evolving people leadership responsibilities as the organization scales
• Mentor and coach scientists, genetic counselors, and operational partners, fostering a culture of continuous learning, accountability, and scientific excellence
• Collaborate cross-functionally with Laboratory, Bioinformatics, Product, Quality, Regulatory, IT, and Clinical Development teams to support successful launch of new assays, tools, and initiatives
• Provide input into strategic planning, organizational design, and capacity modeling through data-driven insights
• Foster a culture of operational excellence, best practices, and professional growth
• Perform other duties as assigned in support of departmental and company goals

Benefits

• Employees regularly scheduled to work 20 or more hours per week are eligible for comprehensive benefits including: Medical, Dental, Vision, Life, STD/LTD, 401(k), Paid Time Off (PTO) or Flexible Time Off (FTO), Tuition Reimbursement and Employee Stock Purchase Plan.
• Casual, PRN & Part Time employees regularly scheduled to work less than 20 hours are eligible to participate in the 401(k) Plan only.
• Employees who are regularly scheduled to work a 7 on/7 off schedule are eligible to receive all the foregoing benefits except PTO or FTO.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree