Chief of Staff, Fractional

Parallel Bio•San Francisco, CA

1d•Onsite

About The Position

At Parallel Bio, we are leveraging the human immune system to unlock safer, more effective drugs. We believe immunotherapies are the future of medicine, but their discovery is hindered by outdated models that fail to capture the complexity of the human immune system. Our platform overcomes these challenges by combining best-in-class human immune organoids with massive scale and advanced computational methods, including AI and machine learning. This allows us to generate unprecedented, population-scale insights into human health and disease. We can rapidly discover new drugs that we know will work in patients from the start and understand how they will perform across an entire population—something not possible with today's technology. This knowledge will allow us to engineer therapies that will work for as many people as possible, ensuring a safe and effective cure for everyone. We are a fast-paced, venture-backed company at a pivotal moment of growth. Join us on our journey as we create new tools to push the boundaries of what is possible. We’re looking for a Fractional Chief of Staff to bring structure, accountability, and operational excellence to every part of Parallel Bio as we scale. This is a high-impact role for someone who thrives at translating strategy into action—designing systems that help a fast-moving team execute and deliver results. You'll be the connective tissue across leadership and teams, ensuring that what we decide actually gets done. You’ll drive the rhythm of the organization: setting sprint cadence, ensuring tasks have owners, and holding teams accountable for measurable outcomes. You’ll partner across functions to make sure cross-functional projects move forward—on time, on track, and with clear visibility into progress and blockers. You’re an expert in tools like Asana, Notion, and Slack and know how to use them not just for organization, but for alignment, visibility, and momentum. If you love creating clarity out of complexity, coaching teams toward operational rigor, and helping founders scale their impact, you’d be the perfect person to join our team.

Requirements

Experience: 5+ years supporting senior leadership or operations in at least two startups or high-growth teams in biotech, deep tech, or science-driven environments.
Tool Mastery: Deep expertise in Asana (task design, dependencies, boards), Notion (documentation systems, dashboards), and Slack (automation and integrations).
Structured Thinking: You’re wired to bring clarity and order—breaking big goals into trackable milestones.
Execution Mindset: You don’t just plan; you ensure progress happens and deliverables are met.
Clear Communication: You write and speak with influence, enabling alignment without micromanagement.
Start-up Agility: Comfortable with ambiguity, you make fast, pragmatic decisions and keep others moving forward.

Responsibilities

Design and manage the cadence of leadership meetings, project sprints, and progress reviews.
Build accountability systems in Asana to ensure initiatives have clear ownership, scope, and timelines.
Keep priorities visible and current, surfacing blockers early and ensuring follow-through on commitments.
Partner with leadership to translate company goals into actionable project plans.
Ensure cross-functional projects move forward by coordinating dependencies, clarifying ownership, and tracking deliverables.
Facilitate alignment across Science, Technology, Operations, and Executive teams.
Centralize decisions, documentation, and updates in Notion and streamline communication via Slack.
Audit and refine how we use Asana, Notion, and Slack to ensure they work together seamlessly.
Develop dashboards to track progress and metrics across company-wide initiatives.
Implement workflows that reduce noise and optimize information flow between functions.
Support founders in prioritization, planning, and maintaining organizational focus.
Coordinate critical initiatives spanning multiple functions, tracking progress and outcomes end-to-end.
Step in to own high-priority special projects as the company evolves.