Chemist (R1-R5)

Lilly • Boston, MA

1d

About The Position

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
Eli Lilly and Company seeks a Chemist (R1-R5) to perform quantitative analysis in support of RNA therapeutics development. Identify metabolites of oligonucleotides using high resolution mass spectrometry and liquid chromatography-mass spectrometry. Design and conduct in vitro and in vivo studies to assess siRNA-based modalities for efficacy, exposure, potency, and durability. Enable platform development through in vitro stability assays. Conduct analytical assay development for siRNA-based modalities in connection with pre-portfolio, portfolio, and candidate selection. Develop analytical methods to support antibody conjugated-siRNA programs. Develop alternative methods for tissue homogenization to improve throughput and sensitivity. #LI-DNI

Requirements

• Bachelor’s degree in Chemistry, Biochemistry, Pharmaceutical Science, or a related field
• 3 years of experience with performing quantitative biochemical analyses in an industrial or research organization setting.
• 3 years of experience with leveraging high-performance liquid chromatography-mass spectrometry (HPLC-MS) for bioanalysis
• 3 years of experience with high-resolution mass spectrometry tools, including Orbitrap/TOF
• 3 years of experience with handling biological tissues and fluids in a research laboratory setting
• 3 years of experience with conducting oligonucleotide bioanalysis
• Up to 5% domestic and international travel required.

Responsibilities

• Perform quantitative analysis in support of RNA therapeutics development.
• Identify metabolites of oligonucleotides using high resolution mass spectrometry and liquid chromatography-mass spectrometry.
• Design and conduct in vitro and in vivo studies to assess siRNA-based modalities for efficacy, exposure, potency, and durability.
• Enable platform development through in vitro stability assays.
• Conduct analytical assay development for siRNA-based modalities in connection with pre-portfolio, portfolio, and candidate selection.
• Develop analytical methods to support antibody conjugated-siRNA programs.
• Develop alternative methods for tissue homogenization to improve throughput and sensitivity.

Benefits

• Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance).
• Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Number of Employees: 5,001-10,000 employees