Biophysicist Surface Plasmon Resonance

Bureau Veritas•Leadville, CO

8d•$45 - $51

About The Position

The Biophysicist, Surface Plasmon Resonance is responsible for hit-to-lead discovery efforts by employing multiple technologies to characterize small molecule-protein, protein-protein, and other complex interactions. Duties and Responsibilities:It is everyone’s responsibility to live out our Values and Absolutes by Shaping a World of Trust while ensuring responsible progress.

Requirements

Direct experience in large or small molecule assay development for SPR.
Chemical labeling methods and technologies.
Experience using automation technologies (e.g. SPT Labtech, Tecan) programming and method development.
Experience in fluorescent-based methods or assay development (e.g. FP, FRET, etc.).
Working knowledge in assay development and utilizing BLI (e.g. Octet) and method development
Committed to staying current with the latest scientific breakthroughs in structure-based drug design and biophysical analysis.
Highly organized with excellent analytical, documentation and multi-tasking skills.
Proven ability to work in a flexible, team-oriented environment.
Excellent interpersonal skills with the ability to communicate and interact well with colleagues at all levels.
Full method development skills
Champions Company Values
Bachelor’s of Science in Biochemistry, Chemical Biology, or a related field.
2+ years of hands-on experience with SPR (e.g. Biacore, Bruker, or Caterra) and sound knowledge of various immobilization techniques.

Nice To Haves

Master’s Degree preferred

Responsibilities

Characterize protein-ligand and protein-protein interactions primarily by SPR (Surface Plasmon Resonance). However, a variety of methods may also be used including but not limited to; Bio Layer Interferometry (BLI), fluorescence spectroscopy, light scattering techniques, intact protein mass spectrometry, and DSF.
Biophysically characterize protein samples destined for multiple workflows.
Use biophysical tools to interrogate protein-ligand and/or protein-protein interactions to triage or advance compound or large molecule series.
Learn and develop technical expertise in protein biochemical and biophysical characterization across multiple platforms which may lay outside the current skill set.
Develop and continually advance one’s knowledge base on genetically targeted drugs and structure-based drug design.
Adapt to highly dynamic project priorities, with diligent and rapid communication of scientific results and insights to the team, including maintaining an ELN and uploading data to the database.
Perform work in compliance with company Research Policies.
Perform final review and interpret data / reports. Perform critical error review.
Review and close root cause analysis and corrective actions.
Works directly with external contacts to implement new testing or process initiatives.
Assist in the coordination of technical & administrative aspects of various departmental projects, providing direction to techs.
Perform background/literature research to help further research goals.
Conduct operational audits to identify defects and inconsistencies.
Reviews contract requirements prior to testing in order to assure adherence to client requirements, and coordinates testing between labs.
Perform final review and interpret data / reports for external regulatory agencies.
Write, implement and update SOPs, test protocols, and technical procedures to facilitate department development and improve quality.
Method development – write and adapt custom methodology for custom materials
Follow the guidelines set forth with clients and in the Bureau Veritas Consumer Products Services, Inc Quality, Health, Safety, Security and Environmental policies and procedures.
Comply with clients and Bureau Veritas Consumer Products Services, Inc management systems in accordance with appropriate regulatory agencies.
Follows the guidelines set forth in by clients and the Bureau Veritas Consumer Products Services, Inc Quality Manual and Safety / Chemical Hygiene Plan.
Other duties as defined by Manager, department needs and workload.