Biophysicist/Biomolecular Mass Spectrometrist

Bureau Veritas•Leadville, CO

7d•$45 - $51

About The Position

The Biophysicist/ Biomolecular Mass Spectrometrist is responsible for hit-to-lead discovery efforts by employing multiple technologies to characterize small molecule-protein, protein-protein, and other complex interactions.

Requirements

Full method development skills and hands-on sound experience of LC mass spectrometry techniques and equipment (e.g. QToF, ToF, Orbitrap)
Direct experience in LCMS assay development.
Highly organized with excellent analytical, documentation and multi-tasking skills.
Proven ability to work in a flexible, team-oriented environment.
Excellent interpersonal skills with the ability to communicate and interact well with colleagues at all levels.
Working knowledge of chemical labeling methods and technologies.
Working knowledge of automation technologies (e.g. SPT Labtech, Tecan).
Committed to staying current with the latest scientific breakthroughs in structure-based drug design and biophysical analysis
Champions Company Values
Bachelor’s of Science in Biochemistry, Chemical Biology, or a related field.
Minimum of two (2) years of hands-on experience with mass spectrometry technologies (e.g. QToF, ToF, Orbitrap) and sound knowledge of LC techniques.

Nice To Haves

Master’s Degree preferred

Responsibilities

Work closely with senior scientists to accomplish team objectives and research milestones.
Apply automation and a variety of intact mass spectrometry techniques to determine kinetic and fixed timepoint constants for protein-ligand interactions.
Employ Genedata Expressionist and Screener workflows to analyze and report mass spectrometry data to project teams within consistent timelines.
Maintain and troubleshoot Agilent LC-ESI-QToF mass spectrometry instruments to ensure reliable operation and quality data acquisition.
Learn and develop technical expertise in protein biochemical and biophysical characterization across multiple platforms which may lay outside the current skill set.
Develop and continually advance one’s knowledge base on genetically targeted drugs and structure-based drug design.
Adapt to highly dynamic project priorities, with diligent and rapid communication of scientific results and insights to the team, including maintaining an ELN and uploading data to the database.
Perform final review and interpret data / reports. Perform critical error review.
Review and close root cause analysis and corrective actions.
Works directly with external contacts to implement new testing or process initiatives.
Assist in the coordination of technical & administrative aspects of various departmental projects, providing direction to techs.
Perform background/literature research to help further research goals.
Conduct operational audits to identify defects and inconsistencies.
Reviews contract requirements prior to testing in order to assure adherence to client requirements, and coordinates testing between labs.
Perform final review and interpret data / reports for external regulatory agencies.
Write, implement and update SOPs, test protocols, and technical procedures to facilitate department development and improve quality.
Method development – write and adapt custom methodology for custom mat
Follow the guidelines set forth with clients and in the Bureau Veritas Consumer Products Services, Inc Quality, Health, Safety, Security and Environmental policies and procedures.
Comply with clients and Bureau Veritas Consumer Products Services, Inc management systems in accordance with appropriate regulatory agencies.
Follows the guidelines set forth in by clients and the Bureau Veritas Consumer Products Services, Inc Quality Manual and Safety / Chemical Hygiene Plan.
Other duties as defined by Manager, department needs and workload.