Biologist (50849)
About The Position
Position Objective: Provide services as a Biologist in support of the overall functions of the Vaccine Production Program (VPP), Vaccine Research Center (VRC) within the National Institute of Allergy and Infectious Diseases (NIAID). Duties and Responsibilities: Develop downstream (purification) processes, under the supervision of a project lead scientist, for recombinant proteins, virus vaccines, and virus-like particles (VLP) that may be used as clinical candidates. Work collaboratively within the purification group to design, develop and optimize chromatography and filtration step unit operations to support process development of clinical trial vaccine candidates and mAb products. Purify research-phase recombinant proteins, virus vaccines and/or virus-like particles in support of other groups or external collaborators. Work to prepare necessary materials (buffers, packed columns, etc.) in support of downstream process activities. Support technology transfer of processes to Lab’s Pilot Plant for manufacture of clinical product through document generation and on-site support. Write and review technical protocols and reports. Analyze and compile data, present at various group/department meetings. Coordinate with project management to ensure development milestones and study deliverables are met in a timely manner Work with VPP Data Science and Automation (DSA) group to create platform data analysis/visualization packages using Tableau or equivalent software Support mRNA-Lipid Nanoparticle (LNP) program by designing and executing process development studies for mRNA-lipid nanoparticle encapsulation Serve as SME with operation and optimization of microfluidic systems, e.g. Precision NanoSystem, Inc Ignite and Blaze, and/or Knauer NanoScaler Impingement Jet Mixers Perform scale down and scale-up operations to support tech transfer to manufacturing and/or troubleshooting
Requirements
- Bachelor’s degree in Bioengineering, Chemical Engineering, Biochemistry, or a related discipline.
- 1-2 yr experience in recombinant protein purification development for GMP clinical-phase products.
- Familiarity with computer software including word processing and data evaluation.
Nice To Haves
- Demonstrated knowledge of maintaining accurate and detailed records.
- Must be a team player who can effectively work with members from cross-functional departments.
- Strong oral and written communication skills.
- Ability to communicate effectively, orally and in writing, with non-technical and technical staff.
- Detail-oriented and possess strong organizational skills with the ability to prioritize multiple tasks and projects
Responsibilities
- Develop downstream (purification) processes for recombinant proteins, virus vaccines, and virus-like particles (VLP).
- Design, develop and optimize chromatography and filtration step unit operations.
- Purify research-phase recombinant proteins, virus vaccines and/or virus-like particles.
- Prepare necessary materials (buffers, packed columns, etc.) in support of downstream process activities.
- Support technology transfer of processes to Lab’s Pilot Plant.
- Write and review technical protocols and reports.
- Analyze and compile data, present at various group/department meetings.
- Coordinate with project management to ensure development milestones and study deliverables are met in a timely manner
- Work with VPP Data Science and Automation (DSA) group to create platform data analysis/visualization packages using Tableau or equivalent software
- Support mRNA-Lipid Nanoparticle (LNP) program by designing and executing process development studies for mRNA-lipid nanoparticle encapsulation
- Serve as SME with operation and optimization of microfluidic systems
- Perform scale down and scale-up operations to support tech transfer to manufacturing and/or troubleshooting
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Mid Level
