Associate Director, Computational Chemistry

Takeda • Boston, MA

3d • Hybrid

About The Position

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible to bring life-changing therapies to patients worldwide. Objective / Purpose: As a Senior Computational Chemistry Leader, you will work as part of a multi-disciplinary team of Medicinal Chemists, Computational Chemists, Data Scientist, Structural Biologists, Pharmacologists and Biologists to provide Computational expertise to advance drug discovery projects. This role supports small molecule research initiatives across Takeda research sites, leading computational chemistry efforts to drive project progression at both locations. Implement and execute innovative computational methodologies and tools such as AI, free energy, and cheminformatics approaches to support drug discovery efforts

Requirements

• Expertise in a variety of computational tools and methodologies including docking, virtual screening, molecular dynamics, free energy perturbation, homology modeling, quantum mechanics, pharmacophore elucidation, data mining, machine learning, cheminformatics, clustering, similarity & diversity analysis.
• Significant Industry experience contributing as Computational Chemist on drug discovery projects.
• Strong Impact in progressing Discovery Projects from Hits to Clinical Leads
• Extensive knowledge & experience in using a variety of tools for Hit ID
• Proficiency with state-of-the-art Computational Chemistry software.
• PhD degree in a scientific discipline with 7+ years of Industry (pharma/biotech) drug discovery experience required

Nice To Haves

• Experience in a supervisory role is strongly preferred.

Responsibilities

• Demonstrate expert understanding of computational chemistry principles and their application within a multidisciplinary drug discovery environment.
• Identify, develop, validate, and implement innovative computational approaches that improve research productivity and success.
• Provide crucial technical knowledge and input to project teams to drive decision-making in drug discovery projects.
• Build and develop a strong team of Computational Chemists to high productivity levels.
• Provide project teams with computational strategies to inform, influence, and prioritize compound designs for potency/selectivity and improve ADME/Tox endpoints.
• Ability to effectively integrate emerging generative chemistry methods and other modern machine learning and artificial intelligence (AI) applications in small molecule drug discovery.
• Identifies, plans and executes novel scientific projects and lead platform initiatives.

Benefits

• U.S. based employees may be eligible to participate in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and well-being benefits, among others.
• U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

What This Job Offers

• Job Type: Full-time
• Career Level: Director
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees