Pfizer-posted 1 day ago
Full-time • Mid Level
Hybrid • Groton, CT
5,001-10,000 employees

The Senior Computational Toxicologist (Chemistry-focused) will lead and support informatics-driven initiatives to integrate chemical and toxicology datasets aimed at improving the overall nonclinical drug discovery and development decision-making and processes, including but not limited to the reduction of currently required toxicity studies, the analysis, uptake and incorporation of new approach methods (NAMs) and the integration of multi-modal data to improve portfolio and study-level decision-making. This role combines advanced computational approaches with toxicology expertise to enable data-driven decision-making across drug discovery and development. The position will focus on building scalable data architectures and applying artificial intelligence/machine learning to transform drug safety assessment by advancing innovative approaches such as hybrid and virtual control study design implementation and multimodal predictive toxicology modeling.

  • Apply advanced R and/or Python programming for data processing, visualization, and statistical modeling.
  • Implement machine learning workflows to predict toxicological outcomes and support AI-enabled safety assessments.
  • Design, develop, curate, and maintain robust databases for chemical and toxicology data, ensuring data quality and compliance with Pfizer data standards.
  • Collaborate with toxicologists, pathologists, data scientists, and informatics teams to integrate multi-modal datasets (chemical structures, in vitro/in vivo toxicology data) into next generation predictive toxicology models.
  • Contribute to foundational data architecture strategies and implementation to enable AI-driven insights.
  • Ensure data integrity, security, and adherence to regulatory requirements, while contributing to best practices for coding workflows, version control, and comprehensive documentation to support reproducibility and transparency.
  • Communicate findings through reports, presentations, and publications to internal stakeholders and external scientific forums.
  • Stay current with emerging computational toxicology methods and actively participate in team discussions to improve workflows and approaches.
  • Master's in Computational Chemistry/Toxicology, Chemistry, Toxicology, Data Science, or related field with 2+ years of experience
  • Ph.D. in Computational Chemistry/Toxicology, Chemistry, Toxicology, Data Science, or related field with 0+ years of experience
  • Deep expertise in R and/or Python for data analysis and modeling following coding best practices, including version control, structured workflows, documentation, and reproducibility standards.
  • Proven experience in database creation, management, and analysis
  • Expertise in machine learning techniques and their application in chemical, biological and/or toxicological sciences.
  • Understanding of data architecture principles to support AI workflows.
  • Strong communication, collaboration, and problem-solving abilities.
  • Experience with cloud-based data platforms and big data technologies.
  • Knowledge of cheminformatics tools and toxicology ontologies and datasets (working with SEND formatted data).
  • Track record of publications in computational toxicology or related fields.
  • Working knowledge of toxicology data, including chemical safety assessments and regulatory frameworks
  • Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
  • participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program
  • comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments
  • Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage.
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