Assay Development Senior Research Associate/Associate Scientist

Invivyd Inc.•Newton, MA

49d•Onsite

About The Position

In this role you will design, develop and execute functional assays for a cutting-edge antibody discovery platform. This involves applying a breadth of techniques in the virology, molecular biology, cell biology, and immunology spaces to advance innovative biotherapeutic products through discovery and pre-clinical development stages at Invivyd. This is a unique opportunity to join Invivyd's Antibody Discovery and Preclinical Development Team which generates and characterizes human therapeutic antibody candidates against infectious disease targets like SARS-CoV-2, influenza, and RSV. The Assay Development Senior Research Associate will serve as a key member of the discovery team, provide expert input, and execute new and established methods to meet project requirements and timelines.

Requirements

Master's degree or Bachelor's degree and 6+ years of bench Industry experience in virology, molecular biology, cell biology, or other life science disciplines.
High proficiency in mammalian cell culture is required.
Previous experience working with virus in a BSL-2 setting is required.
Ability to interpret in-process readouts for the purposes of assay optimization and troubleshooting.
Proactive team player and flexibility to work on multiple projects as the discovery programs evolve over time.
Excellent verbal and written technical and non-technical communication skills.

Nice To Haves

Previous experience designing and optimizing cell-based assays and functional antibody characterization is highly preferred.
Mammalian cell transfection with an understanding of expression vector design is highly preferred.
Strong understanding of molecular biology and experience with DNA construct design and sequence analysis is highly preferred.

Responsibilities

Development and independent troubleshooting of virus-based antibody screening functional assays and optimization of existing assays.
Contribute to high-impact projects within the Discovery group by characterizing lead antibody molecules for pre-clinical studies.
Design and perform experiments involving in vitro screening and characterization of antibody drug candidates using immunological, biochemical, and cell-based assays.
Design and generate pseudoviruses for use in evaluation of antibody candidates.
Generate authentic viruses in a BSL-2 setting for use in evaluation of antibody candidates.
Perform molecular design and characterization of DNA constructs used for assay development.
Execute basic molecular biology (DNA/RNA extraction, RT-PCR, PCR, cloning, etc.) and Cell Biology (mammalian cell culture, gene transfection and expression) to support antibody discovery efforts.
Collaborate closely across an interdisciplinary biologics research team to drive antibody discovery campaigns.
Employ high-throughput molecular biology methods for building new vectors and libraries.
Maintain appropriate records e.g. lab notebook, protocols, reports, data integrity.
Present data, both orally and as written reports, to internal stakeholders.