Advisor, Preclinical Pharmacology
About The Position
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Organization Overview: We are seeking a highly accomplished and collaborative Advisor to lead our in vivo preclinical pharmacology efforts within the Preclinical Sciences group at Verve Therapeutics, a wholly owned subsidiary of Eli Lilly. In this role, you will serve as a scientific and operational leader, guiding a dedicated team to advance cardiometabolic gene editors from early concept through to fully characterized development candidates. You will work at the intersection of innovative gene editing technologies and translational science, contributing directly to programs that have the potential to transform patient outcomes.
Requirements
- Ph.D. in biochemistry, molecular biology, pharmacology, pharmaceutical sciences, chemistry, or a related field, with 5+ years of industry experience in preclinical pharmacology research.
Nice To Haves
- Extensive experience in cardiometabolic disease biology and established proficiency with relevant preclinical disease models.
- Strong background in gene therapy or gene editing technologies, including CRISPR, base editing, or related modalities.
- Direct experience managing scientific collaborations with contract research organizations (CROs) or overseeing outsourced research programs.
- Deep scientific expertise in preclinical physiology and pharmacology, with a demonstrated track record of advancing programs in a drug discovery or development setting.
- Exceptional verbal, written, and presentation communication skills, with strong attention to detail.
- Proven ability to work effectively in cross-functional, matrixed environments with strong interpersonal and collaborative skills.
- Sound problem-solving and decision-making capabilities, with the ability to provide and receive constructive scientific feedback.
Responsibilities
- Lead and mentor an in vivo pharmacology team, establishing a high-performance scientific culture focused on rigor, reproducibility, and innovation.
- Develop and use preclinical disease models to establish proof-of-concept (POC) and advance program-critical objectives.
- Define and implement a robust set of pharmacodynamic biomarkers to characterize compound activity in vivo.
- Evaluate and communicate the translatability of preclinical PK/PD relationships to human biology, informing dose selection and clinical strategy.
- Partner with matrixed cross-functional teams to complete comprehensive preclinical data packages in support of development candidate nomination.
- Oversee the end-to-end planning, coordination, and execution of external and internal IND-enabling studies, ensuring alignment with program timelines and organizational priorities.
- Collaborate effectively with scientific, technical, and operational partners to maintain study quality and delivery commitments.
- Manage external and internal mouse colonies ensuring data integrity and operational continuity.
- Author and critically review preclinical reports, pharmacology summaries, and relevant sections of regulatory submissions.
- Evaluate and champion the integration of emerging technologies and platforms that enhance data quality, operational workflows, and scientific rigor.
Benefits
- Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
Number of Employees
5,001-10,000 employees
