2026 Summer Intern – Integrative Immunogenomics
About The Position
The Human Genetics organization advances discovery and translational science by integrating large-scale genomic data with disease biology to generate insights that inform drug discovery and precision medicine. Our work spans autoimmune disease, inflammation, and oncology, with a strong emphasis on immune-mediated mechanisms and causal inference. This internship provides doctoral-level trainees with the opportunity to contribute to high-impact, business-critical research at the intersection of human genetics, immunology, and computational biology. This internship position is located in South San Francisco, on-site. As an Integrative Immunogenomics Intern, you will lead a focused research project leveraging whole-genome sequencing data and advanced variant calling outputs to understand how structural variation, somatic variation, and HLA diversity influence immune pathways relevant to disease risk and therapeutic response. Analyze whole-genome sequencing datasets to characterize structural variants, clonal hematopoiesis (CHIP) events, and HLA class I/II variation in immune-related genes. Integrate genomic findings with immune pathway and gene-set resources (e.g., Reactome, InnateDB, Open Targets). Assess associations between genetic features and immune or inflammatory phenotypes across selected disease areas, including autoimmunity and immune-oncology. Summarize results at the gene- and pathway-level to support ongoing pathobiology mapping and translational research efforts. Communicate findings through a final written report and oral presentation to cross-functional scientific stakeholders. Program Highlights Intensive 12-week, full-time (40 hours per week) paid internship. Program start dates are in May/June (Summer) A stipend, based on location, will be provided to help alleviate costs associated with the internship. Ownership of challenging and impactful business-critical projects. Work with some of the most talented people in the biotechnology industry.
Requirements
- Must be pursuing a PhD (enrolled student).
- Must be pursuing a PhD in Genetics, Genomics, Bioinformatics, Immunology, Computational Biology, or a closely related field.
- Demonstrated experience analyzing genomic or high-dimensional biological data.
- Strong programming skills in Python, R, or similar analytical languages.
- Solid foundation in human genetics and molecular biology concepts.
- Ability to synthesize complex data into clear, actionable insights.
- Excellent written and verbal communication skills.
Nice To Haves
- Experience with whole-genome sequencing data and variant interpretation.
- Familiarity with structural variants, somatic variation, or HLA typing.
- Background or strong interest in immune biology, autoimmunity, or cancer immunology.
- Experience working in collaborative, multidisciplinary research environments.
- Complements our culture and the standards that guide our daily behavior & decisions: Integrity, Courage, and Passion.
Responsibilities
- Analyze whole-genome sequencing datasets to characterize structural variants, clonal hematopoiesis (CHIP) events, and HLA class I/II variation in immune-related genes.
- Integrate genomic findings with immune pathway and gene-set resources (e.g., Reactome, InnateDB, Open Targets).
- Assess associations between genetic features and immune or inflammatory phenotypes across selected disease areas, including autoimmunity and immune-oncology.
- Summarize results at the gene- and pathway-level to support ongoing pathobiology mapping and translational research efforts.
- Communicate findings through a final written report and oral presentation to cross-functional scientific stakeholders.
Benefits
- Intensive 12-week, full-time (40 hours per week) paid internship.
- Program start dates are in May/June (Summer)
- A stipend, based on location, will be provided to help alleviate costs associated with the internship.
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Intern
Education Level
Ph.D. or professional degree
