The Bureau of Alcohol and Drug Use Prevention, Care, and Treatment (BADUPCT) works to close gaps and reduce overall morbidity and mortality related to alcohol and substance use among New Yorkers. BADUPCT develops, implements, and evaluates interventions and prevention strategies through contracting of treatment, recovery and support services; policy analysis and development; epidemiology and surveillance; dissemination of treatment and management guidelines; harm reduction initiatives; public and provider outreach and education; and community involvement and interagency collaboration. The Bureau amplifies the voices of those most impacted and focuses on inequitable structural, social, service, and communication factors that drive disparities. Relay, a nonfatal overdose response system, is an initiative providing 24/7 support to individuals transported to hospital emergency departments (EDs) following a non-fatal opioid overdose. Wellness Advocates visit patients in the ED to provide immediate support and overdose prevention training following an overdose event and offer ongoing support and linkage to care for a maximum of three months after hospital discharge.