Vice President, Late-Stage Oncology Clinical Operations

AstraZeneca • Gaithersburg, MD

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About The Position

Join AstraZeneca to lead and modernize how late-stage oncology trials are designed, delivered, and scaled. We’re seeking a visionary VP to shape our Late Development Oncology Clinical Operations strategy and drive high-quality, tech-enabled execution across a portfolio that spans solid tumors and hematology. This is a mission-critical role with global reach, meaningful impact, and the backing to innovate. What you’ll lead Portfolio-wide strategy and execution : Set direction and oversee clinical operations across late-stage oncology, ensuring trials deliver on time, to quality, and within budget. Enterprise-scale operations : Provide leadership for ~1,700 team members across 25 countries, including: Program Management : ~100 team members Study Management : ~200 team members Site Management & Monitoring : ~1,400 team members Clinical excellence at scale : Drive study planning, feasibility, risk management, monitoring, and global patient recruitment—built on standardized, compliant, and continuously improving practices. Digital and AI acceleration : Champion adoption and optimization of AstraZeneca’s digital, data, and AI strategy in clinical operations to improve speed, quality, and patient impact. Cross-functional leadership : Partner with Oncology R&D, BioPharma R&D Clinical Operations, and the Oncology Business Unit. Your most senior reports are core members of Global Product Teams and play leadership roles on Clinical Project Teams. People, partners, and performance : Build a high-performing, future-ready organization; implement flexible outsourcing models; develop best-in-class processes and systems; and own clinical trial budgets and forecasting.

Requirements

• Bachelor’s degree (or equivalent) in a scientific discipline
• Proven leadership of global clinical operations
• Deep oncology clinical operations expertise
• Strong line management
• Exceptional communication and influence
• Cross-boundary collaboration
• Ability to distill complex information
• Functional leadership in resourcing and budget planning

Nice To Haves

• Master’s or PhD

Responsibilities

• Set direction and oversee clinical operations across late-stage oncology, ensuring trials deliver on time, to quality, and within budget.
• Provide leadership for ~1,700 team members across 25 countries
• Drive study planning, feasibility, risk management, monitoring, and global patient recruitment—built on standardized, compliant, and continuously improving practices.
• Champion adoption and optimization of AstraZeneca’s digital, data, and AI strategy in clinical operations to improve speed, quality, and patient impact.
• Partner with Oncology R&D, BioPharma R&D Clinical Operations, and the Oncology Business Unit.
• Build a high-performing, future-ready organization; implement flexible outsourcing models; develop best-in-class processes and systems; and own clinical trial budgets and forecasting.

Benefits

• Short-term incentive bonus opportunity
• Eligibility to participate in our equity-based long-term incentive program (salaried roles)
• Eligibility to receive a retirement contribution (hourly roles)
• Commission payment eligibility (sales roles)
• Qualified retirement program [401(k) plan]
• Paid vacation and holidays
• Paid leaves
• Health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans

What This Job Offers

• Job Type: Full-time
• Career Level: Executive
• Number of Employees: 5,001-10,000 employees