SIP - DSL - Truong Tran, Phuc - 2.24.26.

Argonne National Laboratory • Lemont, IL

11h

About The Position

Intrinsically disordered proteins (IDPs) represent crucial therapeutic targets due to their significant role in disease–approximately 80% of cancer-related proteins contain long disordered regions – but their lack of stable secondary/tertiary structures makes them “undruggable”. While recent computational advances, such as diffusion models, can design high-affinity IDP binders, translating these to practical drug discovery requires autonomous systems capable of reasoning across complex conformational ensembles and orchestrating diverse computational tools at scale. To address this challenge, we designed and implemented StructBioReasoner, a scalable multi-agent system for designing biologics that can be used to target IDPs. StructBioReasoner employs a novel tournamentbased reasoning framework where specialized agents compete to generate and refine therapeutic hypotheses, naturally distributing computational load for efficient exploration of the vast design space. Agents integrate domain knowledge with access to literature synthesis, AI-structure prediction, molecular simulations, and stability analysis, coordinating their execution on HPC infrastructure via an extensible federated agentic middleware, Academy. We benchmark StructBioReasoner across Der f 21 and NMNAT-2 and demonstrate that over 50% of 787 designed and validated candidates for Der f 21 outperformed the human-designed reference binders from literature, in terms of improved binding free energy. For the more challenging NMNAT-2 protein, we identified three binding modes from 97,066 binders, including the well-studied NMNAT2:p53 interface. Thus, StructBioReasoner lays the groundwork for agentic reasoning systems for IDP therapeutic discovery on Exascale platforms.

Requirements

• The entirety of the appointment must be conducted within the United States.
• Applicants must be: Currently enrolled in undergraduate or graduate studies at an accredited institution. Graduated from an accredited institution within the past 3 months; or Actively enrolled in a graduate program at an accredited institution.
• Must be 18 years or older at the time the appointment begins.
• Must possess a cumulative GPA of 3.0 on a 4.0 scale.
• Must be a U.S. citizen or Legal Permanent Resident at the time of application.
• If accepting an offer, must pass a screening drug test.

What This Job Offers

• Job Type: Full-time
• Career Level: Intern
• Education Level: No Education Listed