TSMS Lab Sr. Principal Process Scientist

Lilly • Lebanon, IN

34d • $66,000 - $171,600

About The Position

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Eli Lilly and Company is seeking a highly motivated and skilled TSMS Lab Sr. Principal Process Scientist to join our dynamic team. This role focuses on the development, optimization, and scale-up of peptide synthesis and/or purification processes. Additionally, this role will be critical in advancing our peptide-based therapeutic pipeline through commercialization, ensuring robust, efficient, and scalable manufacturing processes.

Requirements

• Ph.D. in Organic Chemistry, Medicinal Chemistry, Chemical Engineering, or a related scientific discipline with a strong emphasis on peptide synthesis and purification.
• Minimum of 3 years of relevant experience in peptide process development within a pharmaceutical or biotechnology setting (post-doctoral experience will be considered).
• Demonstrated expertise in both solid-phase and solution-phase peptide synthesis techniques.
• Proficiency in various preparative chromatography techniques, particularly HPLC and MPLC for peptide purification.
• Strong understanding of analytical techniques used for peptide characterization (LC-MS, NMR, UV-Vis, AAA, etc.).
• Excellent problem-solving skills and a strong ability to work independently and as part of a team.
• Outstanding written and verbal communication skills, with the ability to present complex scientific information clearly and concisely.
• Familiarity with cGMP principles and quality systems is a plus.

Nice To Haves

• Experience with process scale-up and technology transfer to manufacturing is highly desirable.

Responsibilities

• Lead and execute laboratory-based research and development activities for the synthesis and/or purification of complex peptides, including solid-phase peptide synthesis (SPPS) and solution-phase peptide synthesis (LPPS).
• Design and perform experiments for process optimization, including reaction conditions, reagent selection, purification strategies (e.g., HPLC, preparative chromatography), and yield improvement.
• Troubleshoot and resolve technical challenges related to peptide synthesis and/or purification, applying a deep understanding of organic chemistry and peptide chemistry principles.
• Collaborate cross-functionally with medicinal chemists, analytical chemists, process engineers, and manufacturing teams to ensure seamless technology transfer and scale-up of peptide processes.
• Document experimental procedures, results, and conclusions thoroughly in laboratory notebooks and technical reports.
• Present findings and recommendations to project teams and senior management.
• Stay abreast of the latest scientific advancements in peptide chemistry, synthesis technologies, and purification techniques.
• Contribute to the development of intellectual property and patent applications.
• Adhere to all safety regulations and good laboratory practices (GLP).

Benefits

• Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance).
• In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree
• Number of Employees: 5,001-10,000 employees