Technical Development Senior Scientist

Genentech • Daly City, CA

7h • Onsite

About The Position

The Pharma Technical Development (PTD) organization is responsible for translating scientific concepts into manufacturable products and ensuring a reliable supply of quality therapeutics to patients. PTD operates through collaboration and continuous process improvement to achieve its mission.
The Global Analytical Development and Quality Control (ADQC) function provides integrated analytical control strategies for the biologics pipeline. This includes developing, validating, and executing physico-chemical, immunochemical, and biological methods. ADQC's work directly supports CMC development, process development, product characterization, and drug delivery for biologics, spanning from early research (molecular assessment) through post-launch activities.
This position is based in South San Francisco, on site.
A Technical Development Senior Scientist position is available in Bioassay US within Genentech’s PTD - ADQC. This is a critical hands-on position designed for an individual eager to develop deep expertise in cell engineering and molecular biology to advance our biotherapeutic pipeline.
You will be directly involved in the creation of next-generation cellular tools, enabling the generation mechanism-of-action (MOA) and characterization assays. This role provides an exceptional opportunity to work under the mentorship of a Technical Development Senior Principal Scientist, implementing cutting-edge technologies to drive the design and progression of novel assays.
If you are passionate about precision cell line engineering and thrive in a fast-paced, inclusive team environment, we encourage you to apply.

Requirements

• Ph.D. in a relevant field (e.g., Cell Biology, Molecular Biology, Bioengineering).
• Demonstrated proficiency in aseptic technique and maintaining cultures of a variety of mammalian cell types.
• Strong fundamental skills in molecular cloning, nucleic acid purification, and design principles for gene expression cassettes, reporters, and knockout strategies.
• Practical experience with nucleic acid delivery methods such as lipofection, nucleofection, and/or viral transduction (e.g., lentivirus).
• Experience with FACS-based methods for analyzing cell surface expression and/or functional reporters.
• Detail-oriented, highly organized, and demonstrated ability to manage and prioritize tasks for multiple projects concurrently.
• Strong oral and written communication skills suitable for documenting work and presenting data to the immediate team.

Responsibilities

• You provide hands-on support for generating and maintaining mammalian cell lines required for functional assays and cell binding.
• Executing specialized molecular biology techniques, including vector design/cloning and production of viral vectors (i.e., lentiviral) to create reporter cell lines and stable expression cassettes.
• Applying CRISPR gene editing and other advanced cellular modification techniques to create precise cellular models for studying drug MOA.
• You perform quantitative analysis of engineered cell lines using techniques like FACS and PCR.
• Driving continuous improvement by incorporating current scientific and innovation trends, and collaborate cross-functionally to acquire necessary data to enable portfolio deliverables.
• You maintain meticulous laboratory records, contribute data to technical reports, present findings at internal group meetings, and represent our work at major external scientific conferences.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree