Systems Integration Scientist

Element Biosciences•San Diego, CA

11d•$110,000 - $145,000•Onsite

About The Position

At Element Biosciences, we are passionate about our mission to empower the scientific community with more freedom and flexibility to accelerate our collective impact on humanity. We have built a highly efficient product-driven organization where employees can learn, grow, and thrive in a challenging but encouraging environment. We are committed to scientific integrity, collegiality, honesty, objectivity, and openness. The System Integration team at Element Biosciences is centered at the interface of product development, evaluation, and optimization. We are seeking an experienced Systems Integration Scientist who will play a pivotal role in testing and validating system-level performance of wet-lab assays on Element sequencers to ensure commercial readiness. This is an incredible opportunity for someone who is passionate about translating complex biochemical workflows into robust commercial products. We are looking for candidates with a solid background in assay development, design of experiments (DOE), and statistical quality control. Experience with troubleshooting assay performance and verification and validation (V&V) of complex biological workflows is a must. This role will report to the VP, Systems Integration and will be a San Diego based role. If you possess the following and want to make a meaningful impact, we invite you to explore this role.

Requirements

PhD in molecular biology, biochemistry, or related field with 2+ years industry experience; or BS/MS with 6+ years of relevant industry experience
Extensive experience in product testing, specifically with NGS assays and in situ fluorescence techniques
Demonstrated proficiency in experimental design and data analysis, capable of performing complex multi-step experiments with detailed attention to protocol
Experience with Design of Experiments (DOE) and statistical analysis (JMP, Python, R) to validate system performance
Strong troubleshooting skills to optimize molecular biology assays and reagent formulations
Familiarity with design controls, verification/validation (V&V), and quality management systems is highly desirable
Experience handling cultured cells and biological specimens is highly desirable
Ability to lift to 20 pounds
The position requires physical activity associated with molecular biology routines and the handling of chemicals
Candidates are required to follow the safety protocols and be familiar with personal protective equipment (PPE) while working in the laboratory environment

Responsibilities

Integrate and test new chemistries and enzymatic methods to improve assay performance, robustness, and reproducibility on the platform
Serve as the primary technical interface between the Biochemistry, Chemistry, and Hardware teams to ensure workflow compatibility with Element’s sequencing platforms
Design and execute comprehensive test plans to verify that assay performance meets product requirements and system-level specifications
Perform verification and validation (V&V) testing of new chemistries and enzymatic workflows on the platform
Create custom test samples and biological controls to rigorously "stress test" system performance and identify failure modes
Analyze complex experimental data to determine pass/fail results and provide detailed feedback on system robustness
Track all changes to assay configurations and perform regression testing to validate the implementation of improvements
Write protocols, test procedures, and maintain accurate records for Design History Files (DHF) and product transfer