Supervisor, Gene Manufacturing

Twist Bioscience • Wilsonville, OR

83d

About The Position

The Gene Manufacturing Supervisor will be very knowledgeable of basic synthetic/molecular biology skills (PCR, vector production, cloning, mini prep, DNA analysis, sequencing, packaging) and will perform, train and/or oversee the production staff on basic molecular biology workflows in a highly automated, high-throughput manner. He or she will be responsible for the manufacture and analysis of a variety of custom gene products across Twist Bioscience's proprietary workflow. The Manufacturing Supervisor will be the main point of contact for shift operators. He or she will assure the staff is working according to the plan of record, will provide guidance, make decisions on priorities and troubleshooting. The Manufacturing Supervisor will also be responsible for leading the pass down of information between shifts.

Requirements

• AS. or B.S. in Biology, Chemistry or Biochemistry.
• 5 year minimum lab experience in manufacturing environment.
• Thorough experience operating liquid handlers such as Hamiltons and Tecans.
• Deep familiarity with molecular biology techniques such as PCR, cell-based cloning, DNA extraction and purification.
• Experience with sample tracking software such as LIMS/MES systems, especially when integrated with liquid-handling robots.
• Experience working within a ISO, GMP, LEAN manufacturing environment.
• Sharp data interpretation acumen.
• A track record of delivering process improvements.
• Laboratory management experience.
• Outstanding communication skills and emotional intelligence.

Responsibilities

• Manufacturing high-quality custom gene products in a high throughput MFG molecular biology lab according to established SOPs.
• Thoroughly maintaining accurate and detailed documentation of all work performed, batch records.
• Operating basic as well as automated lab equipment for molecular biology workflow.
• Tracking the quality metrics by both physical and functional test methods. Initiating any corrective actions necessary to bring production back to expected standards.
• Exercising keen observational skills to proactively identify production problems, then leading technical discussions to provide solutions.
• Upholding standards as defined by the manufacturing process.
• Supporting continuous cost/process improvement initiatives.
• Promoting and prioritizing a safe work environment.
• Maintaining and calibrating lab equipment.
• Leading shift pass-down efforts and prioritizing work to be done.
• Taking accountability for the shift when senior personnel are not on site.
• Acting as advisor to meet schedules and/or resolve technical problems and provides production guidance to junior MFG personnel.
• Scheduling of staff.
• Reviewing and verifying production batch records and manufacturing documents.
• Writing and submitting incident reports, CAPAs, planned deviations etc.
• Following regulatory and ISO 13485 requirements.

Benefits

• Equal Opportunity Employer

What This Job Offers

• Job Type: Full-time
• Industry: Professional, Scientific, and Technical Services
• Education Level: Bachelor's degree
• Number of Employees: 501-1,000 employees