Summer Intern, CMC Process Development
About The Position
The CMC Process Development Summer Intern will support the evaluation and implementation of new technologies for oligonucleotide and antibody conjugation, supporting Arrowhead’s Antibody–Oligonucleotide Conjugate (AOC) and oligo-bioconjugate programs. The intern will contribute to process understanding and optimization efforts aimed at improving manufacturing throughput and crude conjugate impurity profiles. This role provides exposure to cutting-edge bioconjugation technologies, analytical techniques, and collaborative process development in an industrial setting. This is an 11-week Summer Internship Program paying $21.00 per hour and requires full-time, onsite work five days per week at the designated location.
Requirements
- Currently enrolled student at an accredited university or college, sophomore level or higher focused in Chemistry, Biochemistry, or a related field.
- Completion of at least one organic chemistry course.
- Interest in learning and applying a variety of laboratory instrumentation and techniques.
- Excellent verbal and written communication skills, including comfort presenting in group settings.
- Strong problem-solving and organizational skills.
- Proficiency in Microsoft Office applications.
- Ability to lift up to 40 lbs.
- Willingness and ability to spend 75% of the workday in walking around the facility and 25% at a desk
- Ability to work in a laboratory environment for extended periods, including wearing required personal protective equipment (PPE).
Nice To Haves
- Prior exposure to HPLC techniques.
- Previous academic or industry research experience.
- Experience working with macromolecules such as oligonucleotides or proteins.
Responsibilities
- Work closely with CMC Process Development team members to execute experiments using flow chemistry systems and tangential flow filtration (TFF).
- Support process development efforts for AOC programs and oligo-bioconjugates formed off resin.
- Perform analytical characterization of oligonucleotide and antibody intermediates and conjugates using standard HPLC and mass spectrometry (MS).
- Characterize and identify process- and product-related impurities.
- Maintain clear, accurate, and timely documentation of experimental procedures and results.
- Discuss experimental outcomes with team members and contribute to data interpretation.
- Manage time effectively to meet project milestones and internship goals.
Benefits
- Arrowhead provides competitive salaries and an excellent benefit package.
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What This Job Offers
Job Type
Full-time
Career Level
Intern
Education Level
No Education Listed
Number of Employees
501-1,000 employees
