Summer Intern, CMC Process Development

Arrowhead Pharmaceuticals•Verona, WI

4h•Onsite

About The Position

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The CMC Process Development Intern will support process development activities at Arrowhead Pharmaceuticals by contributing to laboratory studies that help improve manufacturing efficiency and product quality. This internship offers hands-on experience working in a laboratory environment, collaborating with scientists, and applying analytical techniques to real-world pharmaceutical challenges. The intern will gain exposure to scale-down modeling, data analysis, and process optimization efforts that support large-scale manufacturing operations. This is an 11-week Summer Internship Program paying $21.00 per hour and requires full-time, onsite work five days per week at the designated location.

Requirements

Currently enrolled student at an accredited university or college, sophomore level or higher focused in Chemistry, Biochemistry, or a related field.
Completion of at least one organic chemistry course.
Interest in learning and applying a variety of laboratory instrumentation and techniques.
Excellent verbal and written communication skills, including comfort presenting in group settings.
Strong problem-solving and organizational skills.
Proficiency in Microsoft Office applications.
Ability to lift up to 40 lbs.
Willingness and ability to spend 75% of the workday in walking around the facility and 25% at a desk
Ability to work in a laboratory environment for extended periods, including wearing required personal protective equipment (PPE).

Nice To Haves

Prior exposure to LCMS techniques.
Previous academic or industry research experience.
Experience working with macromolecules such as oligonucleotides or proteins.

Responsibilities

Perform experiments to assess binding capacity, flow rate performance, FLP recovery, and FLP purity.
Conduct reactions related to oligonucleotide synthesis.
Analyze oligonucleotide samples using analytical techniques such as LC-MS.
Maintain a well-documented laboratory notebook in accordance with established procedures.
Interpret experimental results and support data-driven recommendations.
Present findings from the summer research project during Process Development group meetings.