Staff/Senior Scientist, Proteomics

Glyphic Biotechnologies•Berkeley, CA

1d•Onsite

About The Position

At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing. What we are looking for in you We are seeking a highly analytical, creative, and collaborative Staff/Senior Scientist with a passion for advancing proteomics technologies and workflows. In this pivotal role, you will report to the Vice President of Research and Development where your work will help advance Glyphic’s single-molecule proteome sequencing platform. You will lead the development, optimization, and execution of advanced sample preparation, enrichment, and orthogonal mass spectrometry based proteomics workflows across diverse biological matrices. You will work with a multidisciplinary team that include chemists, molecular biologists, and engineers to drive high-throughput and automated solutions. The ideal candidate is recognized for their expertise with mass-spectrometry based proteomics technologies, and can independently design and troubleshoot complex experiments, critically evaluate data, and communicate findings clearly to both technical and non-technical audiences. Experience with novel enrichment approaches, alternative protein characterization techniques, and automated workflows will be a key asset. In this role, you will have the unique opportunity to directly shape the future of single-molecule protein sequencing, enabling transformative discoveries in life science by making robust, scalable, and real-world-ready sequencing solutions a reality. This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location.

Requirements

Industry experience relevant to the role and an advanced degree in Proteomics, Chemical Biology, Biochemistry, Analytical Chemistry, or a related field including: MS/PhD with 8+/6+ years (for Staff Scientist) MS/PhD with 6+/4+ years (for Senior Scientist)
Strong hands-on experience with LC–MS/MS–based proteomics.
Demonstrated expertise in sample preparation, protein extraction, and enrichment strategies (chemical biology/enrichment strategies preferred).
Proven ability to analyze, interpret, and evaluate mass spectrometry data.
Solid understanding of protein chemistry, post-translational modifications, and quantitative proteomics.
Excellent problem-solving skills and attention to detail.
Excellent written and verbal communication skills, with the ability to work seamlessly with colleagues from diverse scientific and technical backgrounds.
Ability to thrive in a fast-paced environment with evolving priorities.

Nice To Haves

Experience with cell surface proteomics or chemical labeling approaches
Experience with solid phase peptide chemistry
Familiarity with high-throughput proteomics workflows, automation and sample multiplexing
Experience evaluating or implementing alternative protein sequencing or characterization technologies (e.g., O-Link or SomaScan proteomics)
Working knowledge of bioinformatics tools or scripting (e.g., R, Python)
Track record of publications, patents, or technology development
Excellent interpersonal skills – capable of building strong relationships and communicating effectively with stakeholders at all levels.
High emotional and analytical intelligence – able to navigate complex team dynamics, partnerships, and challenges with creativity and logic.
Resourceful adaptability – operates with urgency, remains flexible in evolving environments, and thrives in ambiguity.
Collaborative spirit – enjoys working across disciplines and explaining complex concepts to diverse audiences.

Responsibilities

Sample Preparation & Protein Enrichment Develop and optimize sample preparation workflows for proteomics across diverse biological matrices, including cells and tissues
Design and execute methods to isolate cell surface proteins, including chemical labeling and enrichment approaches
Apply and innovate protein and peptide enrichment strategies (e.g., affinity capture, fractionation, PTM-specific enrichment)
Assess new sample types, determine appropriate analytical strategies, and develop protocols for protein extraction and purification
Collaborate with chemists and engineers to scale workflows and integrate protocols into high-throughput and automated platforms
Experimental Design & Chemical Biology Design and execute mass spectrometry–based proteomics experiments, including discovery, targeted, and quantitative workflows
Apply peptide chemistry techniques, including synthesis, modification, labeling, and derivatization
Utilize chemical biology tools such as probes, crosslinkers, and activity-based reagents to interrogate protein function and interactions
Mass Spectrometry & Analytical Platforms Operate, optimize, and troubleshoot LC–MS/MS systems (e.g., Q-TOF, Astral, nanoLC)
Develop acquisition methods tailored to sensitivity, coverage, and quantitative accuracy
Evaluate and compare LC–MS–based proteomics workflows against orthogonal protein sequencing and characterization technologies, such as antibody-based methods, Edman sequencing, single-molecule protein sequencing, or emerging proteomics platforms
Data Analysis, Evaluation & Technology Assessment Process, analyze, and critically evaluate complex proteomics datasets
Use industry-standard proteomics software and pipelines (e.g., MaxQuant, Proteome Discoverer, Skyline, Spectronaut, PEAKS, or equivalent)
Perform quantitative and statistical analysis to assess data quality, reproducibility, and biological relevance
Stay current with advances in proteomics technologies and advise on platform selection and experimental strategy
Collaboration & Communication Work cross-functionally with chemists, biologists, computational scientists, and engineers
Document methods, generate SOPs, and contribute to best practices
Present results clearly to technical and non-technical audiences

Benefits

Employee Stock Option Plan
100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
Employer Retirement Contributions to 401(k)
Generous Paid Time Off
Paid Maternity and Paternity Leave
Health & Wellbeing Program
Office Snacks and Beverages
Regular Team Bonding Activities

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