Staff Scientist

Guidehouse•Bethesda, MD

2d•$98,000 - $163,000•Onsite

About The Position

We are currently searching for a Staff Scientist to provide analytical and translational research support that will contribute to satisfying the overall operational objectives of the National Heart, Lung, and Blood Institute. This is a full-time, on-site opportunity in Bethesda, MD. In-depth knowledge of molecular and mechanistic studies related to innate immunity and other immune targeting drug therapies as it relates to rejection and fibrosing diseases. Advanced understanding of post-transplant complications, as well as mechanisms of pulmonary fibrosis Conduct standard experimental protocols required for processing and analyzing clinical samples relevant to the research program. Lead mechanism studies and molecular analyses to understand the therapeutic effects of new drug candidates in ongoing or potential clinical trials, with a focus on their anti-sickling effects. Evaluate the translational, mechanistic and clinical benefits of ex vivo models including precision cut lung slices and lung organoid models. Provide scientific leadership and mentorship to postdoctoral fellows, post-baccalaureate trainees, and junior staff to foster their scientific and professional development and facilitate successful completion of scientific projects. Participate in the scientific management and execution of molecular and clinical translational research projects. Conduct independent scientific research to understand mechanisms of rejection after organ transplantation. Contribute to gaining further mechanistic insights into the pathophysiology of transplant rejection, organ injury and fibrosing conditions.

Requirements

PhD in a scientific field
Minimum FOUR (4) years of specialized experience in molecular and translational research.
Specialized experience focusing on molecular pathobiology of immune mediated disease through innate immunity, precision cut lung slices, and/or evaluation of novel therapeutic agents,
Demonstrated mastery of standard experimental protocols.
Experience with mentoring/ supporting postdoctoral fellows, trainees, and junior staff in research and professional development.
Must be able to obtain and maintain a Federal or DoD Public Trust.
Candidates must receive approved adjudication of their Public Trust prior to onboarding with Guidehouse.
Candidates with an active Public Trust or existing suitability are preferred.

Nice To Haves

Ability to be self-motivated, detail oriented, and have strong organizational skills
Strong communications skills, both oral and written
Ability to manage and coordinate high-priority short- and long-term projects and studies in a fast-paced environment

Responsibilities

Provide analytical and translational research support
Conduct standard experimental protocols required for processing and analyzing clinical samples relevant to the research program.
Lead mechanism studies and molecular analyses to understand the therapeutic effects of new drug candidates in ongoing or potential clinical trials, with a focus on their anti-sickling effects.
Evaluate the translational, mechanistic and clinical benefits of ex vivo models including precision cut lung slices and lung organoid models.
Provide scientific leadership and mentorship to postdoctoral fellows, post-baccalaureate trainees, and junior staff to foster their scientific and professional development and facilitate successful completion of scientific projects.
Participate in the scientific management and execution of molecular and clinical translational research projects.
Conduct independent scientific research to understand mechanisms of rejection after organ transplantation.
Contribute to gaining further mechanistic insights into the pathophysiology of transplant rejection, organ injury and fibrosing conditions.

Benefits

Medical, Rx, Dental & Vision Insurance
Personal and Family Sick Time & Company Paid Holidays
Parental Leave
401(k) Retirement Plan
Group Term Life and Travel Assistance
Voluntary Life and AD&D Insurance
Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
Transit and Parking Commuter Benefits
Short-Term & Long-Term Disability
Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
Employee Referral Program
Corporate Sponsored Events & Community Outreach
Care.com annual membership
Employee Assistance Program
Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)
Position may be eligible for a discretionary variable incentive bonus