Staff Scientist ADPE (Protein Sciences)

About the position

Our mission is to develop therapies that empower the immune system to combat neurodegeneration and our team is focused on developing treatments for some of the most challenging diseases facing our society. By harnessing advancements in genetics, immunology and neuroscience, we are pioneering the development of potential therapies to counteract the devastating progression of neurodegeneration. We are supported in this mission by experienced and accomplished scientists and clinicians, a novel portfolio of programs, leading healthcare investors, and pharma company partners, who share in our commitment to bettering the lives of patients and realizing a world where we make brain disorders history. As a Staff Scientist for the antibody discovery and protein engineering (ADPE) group, you'll work closely with scientists in both Research and Development to advance Alector's programs forward. As a member of the Protein Sciences team, you will help to generate therapeutic reagents and biologics with favorable functional and developability profiles.

Responsibilities

• Implement expression/purification/conjugation processes to generate protein reagents at milligram to gram level scales.
• Manage, coordinate, and run developability assessment requests.
• Collaborate extensively across functions and contribute to prioritization and planning within group and project teams to meet company goals.
• Accurately and clearly document experimental notes, protocols, and results.
• Present results at project team and departmental meetings.
• Support development of novel technologies, including high-throughput capabilities, for protein production, analytical, and characterizations.
• Prepare to learn and grow in a highly productive, fun and collaborative environment!

Requirements

• Your academic background includes a PhD in protein biochemistry with 5+ years, MS with 10+ years of therapeutic protein production experience.
• You have proven hands-on expertise in various protein characterization methods and tools including SDS-PAGE, WB, LAL, CE-SDS, Analytical SEC and RP-HPLC, SEC-MALS, DLS, DSF and mass spectrometry.
• You are an expert in protein purification using affinity, IEX, HIC and mixed-mode chromatography.
• You are capable of designing protein purification strategies and trouble-shooting problems independently.
• You have experience with generating difficult-to-produce, low-expressing intracellular, membrane and/or secreted fusion proteins.
• Your expertise in high throughput purification technologies is a plus.
• Your expertise in various site-specific ASO or SiRNA bio-conjugation techniques and DAR determination is a plus.
• Your familiarity with standard text, graphic, and presentation software is required and database/data archival software systems is helpful.
• You have excellent interpersonal, communication and presentation skills with the ability to mentor junior scientists as well as positively influence project direction and strategy.
• You take pride in being self-motivated and a creative problem solver.
• You have a point of view but are low ego.

Benefits

• Flexible hybrid work options
• Competitive compensation
• Comprehensive and unique benefits that enhance your health and well-being