Staff Program Manager, Business Operations

Guardant Health•Palo Alto, CA

40d•Hybrid

About The Position

Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012, Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests, real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care, including screening to find cancer early, monitoring for recurrence in early-stage cancer, and treatment selection for patients with advanced cancer. For more information, visit guardanthealth.com and follow the company on LinkedIn, X (Twitter) and Facebook. Drive effective organizational and operational planning and execution for the Biopharma business, including annual planning cycles, budget tracking, and performance reporting. Partner closely with the SVP and leadership team to coordinate business priorities, manage deliverables, and ensure timely follow-up on key actions and initiatives. Lead the development and management of the Biopharma operating budget, including vendor engagement, purchase order submission, invoice tracking, and collaboration with Finance and Procurement. Oversee vendor management processes for general Biopharma operations, including RFPs, SOW tracking, performance reviews, and contract renewals in collaboration with Legal and Finance teams. Plan and execute major departmental meetings and events, including quarterly business reviews, leadership offsites, and all-hands meetings. Expected to liaise with several teams within Commercial BioPharma team, like: Commercial BioPharma Operations, BioPharma Translational teams. Streamline onboarding for new team members, ensuring consistent processes, materials, and introductions across the Biopharma organization. Implement and refine business processes and tools to improve team efficiency, transparency, and communication across multiple functions and geographies. Serve as a key liaison between Biopharma and cross-functional partners in Finance, Legal, HR, IT, and Corporate Communications. Develop and maintain internal documentation, project trackers, and other organizational tools to support alignment and accountability. Support the preparation of executive materials and presentations for internal and external audiences. May handle expense reporting, light travel and calendaring for SVP. Monitor and report key operational metrics, proactively identifying areas for process improvement and optimization.

Requirements

Bachelor’s degree required; advanced degree preferred.
Typically requires 8+ years of related experience, including program management or business operations type roles within a commercial or biopharma organization.
Demonstrated success managing complex operational programs, budgets, and cross-functional initiatives.
Proven experience with vendor management, including budgeting, contracts, and procurement processes.
Strong organizational and project management skills, with ability to manage multiple priorities and stakeholders simultaneously.
Excellent interpersonal, written, and verbal communication skills; able to build strong working relationships across levels and functions.
High degree of professionalism, discretion, and judgment in handling sensitive and confidential information.
Advanced proficiency with productivity and collaboration tools (e.g., MS Office, Smartsheet, and similar applications).
Demonstrated ability to lead through influence and drive alignment across matrixed teams.

Responsibilities

Drive effective organizational and operational planning and execution for the Biopharma business, including annual planning cycles, budget tracking, and performance reporting.
Partner closely with the SVP and leadership team to coordinate business priorities, manage deliverables, and ensure timely follow-up on key actions and initiatives.
Lead the development and management of the Biopharma operating budget, including vendor engagement, purchase order submission, invoice tracking, and collaboration with Finance and Procurement.
Oversee vendor management processes for general Biopharma operations, including RFPs, SOW tracking, performance reviews, and contract renewals in collaboration with Legal and Finance teams.
Plan and execute major departmental meetings and events, including quarterly business reviews, leadership offsites, and all-hands meetings.
Streamline onboarding for new team members, ensuring consistent processes, materials, and introductions across the Biopharma organization.
Implement and refine business processes and tools to improve team efficiency, transparency, and communication across multiple functions and geographies.
Serve as a key liaison between Biopharma and cross-functional partners in Finance, Legal, HR, IT, and Corporate Communications.
Develop and maintain internal documentation, project trackers, and other organizational tools to support alignment and accountability.
Support the preparation of executive materials and presentations for internal and external audiences.
May handle expense reporting, light travel and calendaring for SVP.
Monitor and report key operational metrics, proactively identifying areas for process improvement and optimization.