Sr. Scientist, Radiopharmaceutical Development

Bristol Myers Squibb

About The Position

RayzeBio, a Bristol Myers Squibb company, is a dynamic biotechnology company headquartered in San Diego, CA. The company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio is developing innovative drugs against targets of solid tumors. Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals The Sr. Scientist, Radiopharmaceutical Development is a leading contributor in the design, development, and advancement of RayzeBio’s radiopharmaceutical programs. This senior role is responsible for translating cutting-edge scientific discoveries into robust clinical drug products and driving technology transfers. The Sr. Scientist will lead CMC radiopharmaceutical process development, oversee IND-enabling activities, and play a pivotal role in clinical manufacturing. This position demands expertise in radiochemical synthesis, analytical techniques, and radiopharmaceutical formulation, as well as a proven ability to manage complex projects and mentor junior staff.

Requirements

BSc +8, MSc + 6 years or PhD +3 years in Chemistry, Radiochemistry, Pharmaceutical Sciences, or related field with relevant industry experience, including significant CMC work with radiopharmaceutical products.
Demonstrated expertise in radiochemical synthesis, purification, formulation, and analytical techniques.
Deep familiarity with federal and state regulatory requirements and safety protocols for radioactive materials.
Advanced experience developing stable radiopharmaceutical formulations with targeted attributes such as extended shelf-life, radiochemical purity, and enhanced bio-distribution.
Hands-on expertise with commercial and custom radiopharmaceutical manufacturing and analytical equipment systems, including automation platforms, radioHPLC, radioTLC, gamma counters, dose calibrators, hot cell manipulators, and advanced gamma spectroscopy.
Extensive experience with a broad spectrum of radioactive materials for both diagnostic and therapeutic applications.
Strong professional ethics, integrity, and ability to maintain confidential information.
Outstanding written and verbal communication skills, with the ability to influence and communicate effectively across all levels, including executive leadership.
Proactive, innovative thinker who thrives in a fast-paced, multi-disciplinary industrial environment.
Demonstrated ability to manage complex research projects and mentor junior staff.

Nice To Haves

Experience in radiopharmaceutical companies leading technology transfers to internal manufacturing or external CDMO partners for Phase 1 clinical programs strongly preferred.
Proven track record of innovation in radiopharmaceutical development.

Responsibilities

Process Development & Scale-Up: Drive CMC process development and optimization for clinical drug products, including formulation lock and robust process definition, ensuring scalability and compliance with regulatory standards.
Technology Transfer: Lead the transfer of advanced radiopharmaceutical processes and technologies to internal and external manufacturing sites, including the Indianapolis facility and CDMO partners.
Laboratory Oversight: Oversee the development, operation, and maintenance of radiochemistry laboratory infrastructure, ensuring readiness for translational activities from preclinical through clinical phases.
Collaboration: Foster collaborative relationships with discovery scientists, external academic partners, and CDMOs to address complex scientific questions and pursue joint research efforts.
Lead Research Initiatives: Independently design and execute advanced radiochemistry and radiolabeling experiments, with a special focus on novel radioisotope and chelator development to enable new classes of radiopharmaceuticals.
Technical Leadership: Serve as a subject matter expert in radiopharmaceutical production processes, quality control, and advanced analytical methodologies. Provide scientific leadership across multidisciplinary teams.
Safety & Compliance: Ensure strict adherence to radiation safety protocols, federal and state regulations, and internal guidelines for handling radioactive materials; promote a culture of safety-first and regulatory compliance.
Data Analysis & Reporting: Interpret complex experimental data, draw scientifically rigorous conclusions, and communicate findings in technical reports, regulatory documentation, and presentations for internal and external stakeholders.
Project Management & Mentorship: Manage and prioritize research projects, oversee third-party vendors, and mentor junior scientists and associates.
Documentation: Draft and review CMC sections for regulatory submissions, SOPs, and comprehensive development reports.

Benefits

Health Coverage: Medical, pharmacy, dental, and vision care.
Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

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