Sr Scientist, Protein Biochemistry

Regeneron Pharmaceuticals • Tarrytown, NY

115d • $108,300 - $176,700

About The Position

Regeneron is seeking a highly motivated and passionate Senior Scientist to join our Protein Biochemistry team. In this exciting role, you will play a critical part in implementing innovative biophysical assessment strategies to support a wide range of drug candidate modalities. This position will also provide matrix-based support for the characterization of novel modalities such as gene therapy agents and oligonucleotides as well as complex therapeutic strategies and approaches.

Requirements

• Ph.D., MS or BS or equivalent degree in biophysics, pharmaceutical sciences, biochemistry, chemical engineering or related field.
• PhD: 0-3+ years, MS: 8+ years, BS: 10+ years proven experience in characterization of therapeutic protein candidates.
• Experience developing and troubleshooting analytical methods.
• Experience with statistical and experimental design, molecular modeling, graphing and mathematical analysis software is a plus.
• In-depth knowledge of and demonstrated expertise operating biophysical and biochemical techniques such as Light Scattering, Analytical Chromatography (SEC, HIC, IEX), Differential Scanning Fluorescence and/or Differential Scanning Calorimetry, Raman, ROA, and/or FTIR spectroscopy, Analytical Ultracentrifugation, Bilayer Interferometry, and Electrospray Mass Spectrometry.
• In-silico modeling skills are a bonus.

Nice To Haves

• Familiarity with biologics development and novel biophysical approaches to drive innovation.
• Ability and passion for independently learning new methods and software.
• Excellent written and verbal communication skills and the ability to prepare slides and author reports and manuscripts for internal and external presentations, communicating biophysical results to both technical and general audiences.

Responsibilities

• Design, develop, and execute biophysical assays supporting developability assessment at different stages of lead characterization.
• Understand current computational biophysics approaches (workflows, software) for in silico modeling of surface properties of antibody-like molecules for in silico profiling.
• Serve as a representative of our department on cross-functional teams with accountability for biophysical characterization.
• Contribute results & analysis for protein or new modality characterization to provide molecular profiles and developability assessments of therapeutic assets, that support the pipeline, in a timely manner and aligned with partner functions.
• Recommending, adapting and developing analytical methods for protein characterization.
• Review the literature and works with their team to design experiments that solve biophysical problems for key partners.
• Supervise and support scientists with critical data review as well as career development.

Benefits

• Comprehensive health and wellness programs.
• Gym memberships.
• Annual bonuses.
• Paid time off for eligible employees.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Industry: Chemical Manufacturing
• Education Level: Ph.D. or professional degree