Sr. Scientist Discovery Proteomics

Amgen-posted 7 months ago

Full-time • Entry Level

Hybrid • South San Francisco, CA

Chemical Manufacturing

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At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Design and implement complex proteomics workflows, including sample preparation, liquid chromatography, and mass spectrometry for both discovery and targeted approaches (e.g., TMT, PRM, label-free DDA & DIA) to support cell surface target discovery.
Use data processing software (e.g., Proteome Discover, Spectronaut, DIA-NN) and collaborate with the bioinformatics team for streamlined data sharing.
Work closely with scientists across functions, present analysis results to stakeholders, collaborate on data integration, and utilize external resources as needed.
Present research findings to colleagues, at scientific meetings (oral or poster presentations) and publish in peer-reviewed journals.
Maintain detailed records of experiments, protocols, and analyses.

Doctorate degree or Master's degree and 3 years of scientific experience or Bachelor's degree and 5 years of scientific experience.

A technical understanding of mass spectrometry and data analysis for quantitative proteomic research, including DDA, DIA, TMT, PTM analysis, with an emphasis on proximity labeling and cell surface proteomics.
Demonstrated capability of troubleshooting and evaluating LC/MS performance.
A proven track record of scientific innovation and accomplishment in mass spectrometry and proteomics, as demonstrated by a strong publication record and conference presentations.
Experience in cell surface proteomic approaches including enrichment methods such as cell surface capture and photo catalytic proximity labeling.
Function optimally in a team-based or collaborative environment as part of a highly integrated team, possess excellent organizational, verbal, and written communication skills, and demonstrate the ability to produce reliable and reproducible results.
Experience with automated sample handlers (e.g. Opentrons, Agilent Bravo AssayMAP, Kingfisher) or other high-throughput approaches.
Demonstrated capability of working with diverse sample types including cell lines, tissues (mass-limited), biofluids and FFPE.

A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan.
Stock-based long-term incentives.
Award-winning time-off plans.
Flexible work models, including remote and hybrid work arrangements, where possible.

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