Sr. Scientist, Clinical Pharmacology

Alnylam Pharmaceuticals

1d

About The Position

The Sr. Scientist in Clinical Pharmacology position will support a rapidly expanding clinical portfolio of promising RNAi therapeutics. The candidate in this position should be well versed in PK and PD with strong ability to critically evaluate and interpret data, conduct noncompartmental analysis, and PKPD modeling. In this role, the candidate is expected to have a strong critical thinking ability with excellent oral and written communication skills.

Requirements

• Ph.D. in Pharmacokinetics, Pharmacology, Pharmaceutics or other relevant field with 2-3 years’ experience in pharmaceutical industry, or M.D or Pharm.D. with equivalent experience. Level and responsibilities will depend on the individual’s experience and interpersonal skills.
• Strong knowledge of clinical pharmacology principles in drug development including PKPD, modeling and simulation, ADME concepts, and clinical pharmacology.
• Hand-on experience in using R and other data visualization techniques for representation of PKPD data.
• Proficient in using Phoenix WinNonlin, Phoenix NLME, R, NONMEM, or other pharmacokinetic, modeling software. Training in application of pharmacometric principles or software would be a plus.
• Strong communication skills (verbal and written) and presentation skills are required. Excellent interpersonal and collaboration skills and the ability to function in a highly matrixed team environment are essential.

Nice To Haves

• Training in application of pharmacometric principles or software would be a plus.

Responsibilities

• Represent Clinical Pharmacology and provide PKPD support and guidance to early and clinical stage project teams.
• Lead the analysis, interpretation, integration and reporting of clinical pharmacokinetic & pharmacodynamic data
• Conduct PK/PD analyses and data visualization to guide development decisions on project teams; ability to use model-based approaches to aid decision making
• Provide PKPD input for regulatory submissions such as briefing documents, IND, CTA and NDA.
• Contribute to protocol preparation, study execution, data review/analysis, study reports and regulatory document preparation
• Closely partner with Research, Bioanalytical, Clinical development, Regulatory, Project Management, biostatistics and other R&D functions.
• Maintain a current understanding of the literature and knowledge in the clinical pharmacology, modeling and simulation field

Benefits

• We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match.
• Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks.
• We also offer generous family resources and leave.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 1,001-5,000 employees