Sr. Scientist, Analytical R&D

MSD•Rahway, NJ

22h•Hybrid

About The Position

Senior Scientist (Protein & Enzyme Analytics) – Data Rich Measurements Job Description: Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology, we collaborate to discover the next medical breakthrough. As a Senior Scientist in Analytical Enabling Capabilities, you will work with a highly collaborative team to advance the development pipeline. You will be primarily responsible for developing analytical methods for complex small molecules, peptides, oligonucleotides, protein-based therapeutics, and emerging modalities in our portfolio. You will work side by side with process chemists to deploy innovative technologies and analytical workflows for high-throughput analysis and characterization across fast-paced laboratory settings (Method Discovery, Protein Engineering, Biocatalysis). As a member of our team, you will be joining a diverse group of scientific problem solvers, who are dedicated to creating the life-changing products of tomorrow.

Requirements

PhD in Chemistry or a related field OR Masters in Chemistry or related field with 5+ years of experience OR Bachelors in Chemistry or related field with 8+ years of experience
3+ years of thorough understanding of chromatography and mass spectrometry within method development.
Creative problem solving in scientific research
Excellent written and verbal communication
Strong track-record of innovation translated into high impact factor publication
Bioanalytical techniques, separations and python coding
LC/MS analysis of proteins/enzymes, HDX-MS and high-throughput analysis
Enzyme kinetics

Nice To Haves

Expertise in method development and troubleshooting of high-throughput fast chromatographic methods including reversed phase, ion exchange, size exclusion chromatography, etc
Hands-on experience in protein characterization techniques such as intact mass analysis, native-MS, peptide mapping analysis for the identification of PTMs, HCPs and disulfide mapping
Strong understanding of designing and executing enzyme kinetics and functional activity assays
Willing to learn new technologies and automation

Responsibilities

developing analytical methods for complex small molecules, peptides, oligonucleotides, protein-based therapeutics, and emerging modalities in our portfolio
work side by side with process chemists to deploy innovative technologies and analytical workflows for high-throughput analysis and characterization across fast-paced laboratory settings (Method Discovery, Protein Engineering, Biocatalysis)