Sr. Research Associate, Discovery Biology

Xencor • Pasadena, CA

383d • $83,500 - $93,500

About The Position

Xencor is a public, clinical-stage biopharmaceutical company located in the Los Angeles area (Pasadena) and in San Diego. Our focus is developing high-potential XmAb bispecific T-cell engagers and additional engineered drug candidates that leverage our differentiated technology platforms, and we are advancing our pipeline toward clinical proof-of-concept decisions. Our goal is to create high-impact therapeutics for patients with cancer and other serious diseases. More than 20 XmAb drug candidates engineered with our technology are in clinical development, and three XmAb medicines have been marketed by partners. We have an excellent opportunity for a Senior Research Associate, Discovery Biology to join our team. This position will be fully onsite at our Pasadena location.

Requirements

• BS in biological sciences, cell biology, immunology, or a related life sciences field with at least 4 years of laboratory work experience is required.
• Advanced proficiency in cell culture with at least 3 years hands-on experience to maintain, expand, and engineer cell lines.
• Experience with human PBMC and human biological tissues or specimens is required.
• Technical expertise in multicolor flow cytometry and associated instrumentation and software with 2 years of experience to operate independently is required.
• Proficiency in common software and data analysis packages such as Microsoft Office, GraphPad Prism, and BD FACS Diva is required.
• Ability to work in a fast-paced, goal-oriented, multi-project environment with adaptability to changing priorities is required.
• Strong interpersonal skills, attention to detail, and professional competencies in oral and written communication are required.

Nice To Haves

• An MS degree in biological sciences with at least 2 years of laboratory work is preferred.
• Experience with high throughput liquid handling and high throughput cell-based assays is desirable.
• Experience with live-cell imaging and impedance-based bioassay platforms is preferred.
• Experience with the Benchling as an ELN and database is desirable.

Responsibilities

• Maintain, expand, and engineer mammalian cell lines and manage primary cell cultures including human immune cells and PBMC.
• Develop and conduct immunological and cellular bioassays to characterize the functional and biological properties and mechanisms of action of antibody and cytokine therapies.
• Support translational studies and preclinical models to evaluate efficacy and safety of antibody and cytokine therapies; no direct animal contact is required.
• Perform best cell culture practices to initiate, maintain, and expand mammalian cell lines and primary human cell cultures.
• Contribute to the design and execution of experiments, analysis, interpretation of data, and reporting and archiving of results.
• Perform immunological and cellular bioassays including cell binding, proliferation, apoptosis, activation, and cytotoxicity assays.
• Attend to daily laboratory operations including the maintenance of equipment, inventories, consumables, reagents, and other supplies.
• Document experimental protocols, assay designs, and results in a laboratory notebook; maintain compliant records, write SOPs, and may contribute to technical reports.
• Contribute to data presentation in departmental or company-wide meetings.
• Follow all laboratory safety guidelines, practices, and protocols.
• Coordinate and collaborate on operational and research-related tasks across multiple groups and departments.

Benefits

• 401k match
• healthcare coverage
• Employee Stock Purchase Plan (ESPP)
• annual bonus
• equity grant

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Industry: Chemical Manufacturing
• Education Level: Bachelor's degree
• Number of Employees: 251-500 employees