About the position
At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do. Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Responsibilities
- Serve as a functional PKDM representative and subject matter expert on the ADME/PK of small molecule therapeutics, collaborating with scientists across our PKDM scientific community.
- Leverage specialized ADME/PK skills such as in vitro ADME, in vivo ADME, biotransformation, PK/PD, or physiologically-based pharmacokinetic modeling (PBPK) to impact project progression and decision-making.
- Plan and execute mechanistic ADME/PK analyses to integrate knowledge of drug design parameters, disease pharmacology, physiology, pharmacokinetics and pharmacodynamics to optimize dose selection and preclinical study designs.
- Contribute to the analysis of pre-clinical ADME and PK data for IND and NDA filings and document these analyses in appropriate reports.
- Build close relationships with partner functions and therapeutic areas.
Requirements
- Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 3 years of directly related experience
- Master's degree and 6 years of directly related experience
- Bachelor's degree and 8 years of directly related experience
Nice-to-haves
- PhD in Pharmacokinetics, Pharmaceutical Sciences, Engineering, or related fields with equivalent professional degrees and 10+ years of experience in the Biotechnology/Pharmaceutical Industry, consulting or post-doctoral training
- Strong background serving as a PKDM functional team representative for discovery or development programs, preferably across therapeutic areas
- Solid technical experience with the application of SM in vitro/in vivo ADME and pharmacokinetics fundamentals to drug discovery projects
- Ability to drive the progression of SM discovery and development within project teams
- Lead development of scientific strategy across PKDM initiatives with a focus on development of mechanistic ADME platforms to aid in translation
- Establish SM workflows for PKDM scientists
- Expertise with in vitro ADME, in vivo ADME, PK/PD or PBPK
- Experience in supporting preclinical components of regulatory documentations
- Excellent interpersonal, technical, and communication skills to lead cross-functional teams
- Past experience as a laboratory scientist in a pharma or biotech environment
- Excellent written and oral communication skills, attention to detail and accuracy, and interpersonal skills
- Record of scientific contributions through peer-reviewed articles and external presentations
Benefits
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models, including remote and hybrid work arrangements, where possible
