Sr. Leader Discovery Toxicology
About The Position
The Senior Director, Discovery Toxicology is responsible for providing scientific and strategic leadership to the Integrative Toxicology function within the Discovery & Translational Sciences (DTS) division. This role oversees the direction and execution of Investigative Toxicology efforts, with a focus on evaluating and mitigating safety risks associated with early-stage therapeutic targets. The position requires a strong foundation in discovery and preclinical toxicology, with the ability to interpret complex data across in vitro, in vivo, and human tissue-based models. The role plays a key part in enhancing the translational relevance of toxicological assessments and supports cross-functional collaboration to advance internal and client drug development programs. This is a remote role.
Requirements
- PhD in Toxicology, Pharmacology, or a related biomedical science, with 15+ years of experience in discovery or investigative toxicology within the pharmaceutical, biotech, or CRO industry.
- Proven expertise in designing and interpreting in vitro, in vivo, and ex vivo toxicology studies to investigate mechanisms of toxicity.
- Track record of successfully supporting drug discovery programs from hit identification through candidate nomination.
- Deep understanding of molecular and cellular toxicology, interspecies differences, drug metabolism, and mechanisms of human relevance.
- Strategic thinker with the ability to synthesize complex scientific data into actionable development plans.
- Strong leadership skills with experience managing and developing scientific teams.
- Excellent communication and cross-functional collaboration skills.
- Proficiency with Microsoft Office Suite (Word, Excel, PowerPoint, Outlook) is required.
Nice To Haves
- Additional qualifications such as DVM or Board Certification in Pathology are strongly preferred.
- Experience in biomarker discovery and translational safety assessments is highly desirable.
Responsibilities
- Design and implement modern toxicology strategies to support all stages of discovery as well as new indications investigations during clients' phased clinical studies and/or post-marketed therapeutics.
- Drive the integration of toxicology as practiced at Inotiv's multiple sites into a single, coordinated network that operates with shared goals, stage-appropriate standards, and best practices.
- Lead mechanistic investigations using in vitro, in vivo, and ex vivo approaches.
- Contribute to the scientific advancement and programmatic inclusion of Novel Alternative Methods (NAM) in the Pharmacologic and Toxicologic assessment of therapeutics
- Evaluate species relevance to improve translatability of nonclinical findings to human risk.
- Collaborate cross-functionally with pharmacology, DMPK, pathology, bioinformatics, and clinical teams to integrate data and guide compound development.
- Contribute to the discovery and application of translational safety biomarkers to support preclinical-to-clinical transitions.
- Anticipate and mitigate safety liabilities early in the discovery process, including off-target effects and distinguishing adaptive from adverse responses.
- Mentor and develop a high-performing team of toxicology investigators and laboratory scientists.
- Represent Discovery Toxicology in internal project teams, governance forums, and external regulatory interactions, as needed.
- Monitor scientific and regulatory advancements to continuously innovate and evolve toxicology strategies.
- Lead a multidisciplinary team including Study Directors, Investigators, and Technical Scientists.
- Complete assigned all assigned training.
- All other duties as assigned.
- Other special projects and duties as assigned
Benefits
- Benefits include health and dental coverage, short- and long-term disability, paid time off, 401K participation with company match, etc.
- Benefits include health and dental coverage, short- and long-term disability, paid time off, paid parental leave, 401K, and more!
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What This Job Offers
Job Type
Full-time
Career Level
Director
Industry
Professional, Scientific, and Technical Services
Education Level
Ph.D. or professional degree
