Sr. Bioinformatics Scientist

Veracyte • South San Francisco, CA

103d • $170,000 - $180,000

About The Position

At Veracyte, we offer exciting career opportunities for those interested in joining a pioneering team that is committed to transforming cancer care for patients across the globe. Working at Veracyte enables our employees to not only make a meaningful impact on the lives of patients, but to also learn and grow within a purpose driven environment. This is what we call the Veracyte way - it's about how we work together, guided by our values, to give clinicians the insights they need to help patients make life-changing decisions. This can be a hybrid position based out of our San Diego office, South San Francisco office, or remote. We are seeking an experienced and motivated Bioinformatics Scientist to join our Bioinformatics and Data Science Team focused on developing regulated diagnostics products. The ideal candidate will bring deep expertise in NGS technologies with a strong understanding of regulatory environments including CAP/CLIA and IVD product development. The successful candidate will play a crucial role in designing, developing, and optimizing our next generation of genomic assays. This position requires a unique blend of expertise in bioinformatics, extensive experience in assay optimization, analytical validation, strong skills in analytical pipeline development, automation and optimization, a deep understanding of molecular biology, and a passion for transforming complex biological data into actionable insights.

Requirements

• PhD or MS in bioinformatics, computational biology, or an adjacent data science field, such as biostatistics, statistics or computer science.
• A minimum of 6 -7 years of experience in bioinformatics analysis, algorithm development, and pipeline implementation.
• Thorough understanding of NGS technologies and various methods for library preparation (WGS, enrichment, RNA-Seq, methylation, etc.).
• Proficiency in quantitative transcriptomics from NGS or expression microarray data in human disease/biology.
• Proficiency in machine learning, development of novel bioinformatics methodologies, and algorithms development.
• Proven experience developing and deploying bioinformatics workflows in AWS.
• Strong proficiency in Python, including experience with testing frameworks and SDLC best practices.
• Close collaboration with Quality and Regulatory Affairs team on assay and analysis pipeline development and verification.
• Demonstrated record of technical and scientific leadership, ownership, and independent work.

Nice To Haves

• Track record of working with wet lab scientists on iterative experiment design, execution, analysis, and interpretation.
• Proficiency in genomics, sequence analysis, and secondary analysis.
• Strong understanding of germline and somatic mutation processes leading to complex variation and genome-wide biomarkers.
• Working knowledge of R.
• Experience with relational and non-relational database technologies.
• Excellent communicator about complex technical topics in an interdisciplinary setting.
• Excellent technical problem solving and troubleshooting skills.

Responsibilities

• Lead bioinformatics design, development and validation efforts in assay development for new and on-market products.
• Apply leading edge knowledge in bioinformatics, genomics, and assay technologies to contribute to development of company's concepts and principles.
• Drive development study design and all analysis for assay development effort in collaboration with cross-functional teams.
• Develop statistical and machine learning techniques to comprehensively evaluate assay performance and create optimization strategies.
• Communicate analysis results, methodologies, and scientific findings to internal teams, external collaborators, and stakeholders.
• Develop scalable, production-grade workflows for high-throughput NGS data analysis using AWS and containerized environments.
• Facilitate successful production pipeline deployment by working closely with infrastructure and engineering teams.
• Ensure compliance with regulatory standards (CAP/CLIA, FDA, IVDR) throughout the bioinformatics development lifecycle.
• Contribute to regulatory submissions and audits by providing technical documentation and validation reports.
• Provide scientific guidance and mentorship to junior bioinformatics team members.

Benefits

• Competitive compensation and benefits.
• Discretionary bonuses/incentives.
• Restricted stock units.
• Career opportunities in a growing company.
• Inclusive workforce fostering diverse backgrounds.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Industry: Ambulatory Health Care Services
• Education Level: Ph.D. or professional degree