Sr. Bioinformatics Scientist – Novel Cell Free DNA Applications

Personalis, Inc•Fremont, CA

2d•$155,000 - $190,000•Hybrid

About The Position

Personalis, Inc. is a leader in advanced genomics for precision oncology. NeXT Personal is an ultra-sensitive, tumor-informed, WGS-based liquid biopsy assay designed to detect minimal residual disease (MRD) and cancer recurrence. It leverages whole-genome sequencing of a patient's tumor and matched normal samples to create personalized panel of up to 1,800 somatic variants, enabling the detection of circulating tumor DNA (ctDNA) at very low levels (down to ~1-3 PPM) in blood samples. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale, and efficiency. Summary: The Senior Bioinformatics Scientist will work with a world-class, dynamic team of bioinformatics scientists, software engineers, and laboratory scientists, developing, testing, and applying cutting-edge cell-free and solid tumor cancer genomics products. Further, the Senior Bioinformatics Scientist will work closely with our clinical evidence generation teams, applying our cell-free technology solutions to large cancer patient cohorts and profiling patient response to therapy with our cfDNA platforms. This position will directly contribute to a new generation of genomics-based precision-medicine products for profiling MRD, ctDNA dynamics, and patient response to treatment. Our products are used by pharma, biotech, hospitals, and clinicians for managing patient treatment and therapeutic selection.

Requirements

Advanced degree (Ph.D.) in bioinformatics, genomics, or a related field
Extensive experience with cancer genomics
Extensive experience with somatic mutational detection and filtering
Experience with cancer liquid biopsy analysis
Proficiency in the application of statistical methods to genomic applications
Proficiency with at least one common programming language (e.g., Python, R)
A track record of designing and implementing experimental approaches to confirm and elaborate upon findings from complex projects
Experience publishing and presenting scientific results

Responsibilities

Design and develop novel cell-free technologies and products
Collaborate closely with laboratory scientists to design experiments to develop and evaluate novel applications for cell-free DNA assays
Draw on deep experience with genomics and statistics to model and improve performance of cell-free assays and features
Synthesize large datasets to develop and evaluate new biological and technological hypotheses
Partner with the clinical evidence generation team to ensure the applicability and evaluate the performance of novel assays or feature improvements
Maintain a strong working knowledge of literature covering technological developments in the cell-free DNA and liquid biopsy space
Publish results and present at conferences in exciting areas, including cell-free DNA and cancer genomics