Sr. Bioinformatics Scientist – cfDNA Technology Development

Personalis•Fremont, CA

1d•$155,000 - $190,000•Hybrid

About The Position

Personalis, Inc. is a leader in advanced genomics for precision oncology. NeXT Personal is an ultra-sensitive, tumor-informed, WGS-based liquid biopsy assay designed to detect minimal residual disease (MRD) and cancer recurrence. It leverages whole-genome sequencing of a patient's tumor and matched normal samples to create personalized panel of up to 1,800 somatic variants, enabling the detection of circulating tumor DNA (ctDNA) at very low levels (down to ~1-3 PPM) in blood samples. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale, and efficiency. Days Onsite: Monday & Tuesday Summary: The Bioinformatics Senior Scientist will work with a world-class, dynamic team of bioinformatics scientists, software engineers, and laboratory scientists, developing, testing, and applying cutting-edge cell-free and solid tumor cancer genomics products. Further, the Bioinformatics Scientist will be working alongside our clinical evidence generation teams, applying our cell-free solutions to large cancer patient cohorts and profiling patient response to therapy with our cfDNA platforms. This position will directly contribute to a new generation of genomics-based precision-medicine products for profiling MRD, ctDNA dynamics, and patient response to treatment. Our products are used by pharma, biotech, hospitals, and clinicians for managing patient treatment and therapeutic selection.

Requirements

Advanced degree (Ph.D.) in bioinformatics, genomics, or a related field
Extensive experience with cancer genomics
Extensive experience with somatic mutational detection and filtering
Experience with cancer liquid biopsy analysis
Proficiency with at least one common programming language (e.g., Python, R)
A track record of designing and implementing experimental approaches to confirm and elaborate upon findings from complex projects
Experience publishing and presenting scientific results

Responsibilities

Design, develop, and build upon our novel cell-free platforms and products, including our NeXT Personal MRD liquid biopsy platform
Work cross-functionally to translate collaborative findings into actively developed cutting-edge products
Design and execute scientific projects and experiments focused on product feature feasibility, demonstrating feature performance and clinical advantages of our cell-free platforms
Modeling and analysis of large, complex genomics datasets using novel methods to generate biological insights
Work with scientific teams to translate scientific findings into actively developed groundbreaking products
Publish results and present at conferences in exciting areas, including cell-free DNA and cancer genomics