Specialist/Senior Specialist, Immunohistochemistry

Immunome, Inc.•Bothell, WA

11d

About The Position

Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugate therapies. Our pipeline includes varegacestat, a late-clinical stage GSI; IM-1021, a clinical-stage ROR1 ADC; and IM-3050, a FAP-targeted radiotherapy that recently received IND clearance. We are also advancing a broad portfolio of early stage ADCs pursuing undisclosed solid tumor targets. Position Overview The Immunohistochemistry Specialist/Senior Specialist will be central to advancing our drug development pipeline. This is a fast paced highly collaborative position which will be key to speeding medicines to patients. You will work cross functionally supporting pre-IND candidates through late-stage development collaborating with internal and external partners.

Requirements

Bachelor’s degree in a life sciences field.
Minimum of 5 years of extensive experience performing histology and assay development in a drug discovery setting including multi-target and multi-species assays in preclinical drug development.
Experienced immunohistochemistry assay development scientist.
Familiarity with several IHC platforms including BondRX along with general IHC core instrumentation.
Ability to prioritize and balance multiple projects simultaneously.

Nice To Haves

Certified histotechnician (HT) or histotechnologist (HTL) highly desired.
Previous experience in antibody-based therapeutics or oncology drug discovery is preferred.

Responsibilities

Perform routine microtomy and staining of single/multi-plex Immunohistochemistry and RNA-ISH.
Independently design, develop, guide, troubleshoot and validate IHC assay development for lead candidate molecules.
Source, procure, and inventory FFPE tissue blocks for project and banking needs.
Use a comprehensive electronic notebook and inventory system to record specimens, reagents, and experimental details.
Perform full slide scanning maintaining an image and slide inventory system
Maintain laboratory supplies and reagents. Participate in general lab upkeep.
Data analysis and interpretation:
Independently and with supervision interpret, understand and communicate complex scientific data to guide rapid decision making.
Leverage expertise to enable decision making within team and cross-functionally.
Project collaboration:
Operate independently and collaboratively within cross-functional teams to design, plan and execute experiments aimed at advancing drug development projects.
Partner and collaborate with colleagues from diverse scientific disciplines, including chemistry, pathology, biomarker, pharmacology, and translational medicine to rapidly achieve project goals.
Collaborate with facilities and EHS to ensure optimal functionality of our lab space and adherence to safety guidelines.
Fearlessly represent IHC team in project team meetings.
Documentation and reporting:
Maintain meticulously detailed and accurate electronic laboratory notebooks documenting experimental procedures, results, and conclusions.
Prepare and present research findings to internal cross-functional teams and contribute to project updates providing histology and assay expertise.
Continuous learning and development:
Readiness and excitement for exploring new avenues and developing new assays in a fast-paced environment.
Stay informed about the latest advancements in techniques for evaluating targeted therapeutics.
Proactively seek opportunities for professional development.
Contribute to and support the scientific growth of the research team.